Investigative Ophthalmology & Visual Science
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#2Ivan NistedH-Index: 1
Last. Toke Bek (Aarhus University Hospital)H-Index: 37
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Purpose Convergence insufficiency (CI) is characterized by abnormal vergence eye movement frequently accompanied by abnormal accommodation and subjective symptoms, such as headache, blurred vision, and diplopia. CI is treated with vergence and accommodation exercises that are integrated so that the relative contributions of vergence and accommodation exercises to the outcome are concealed. The purpose of the present study was to determine the individual contributions of vergence and accommodatio...
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#1Xiang-Yun Liu (Xuzhou Medical College)
#2Yu-Wei Zhang (PKU: Peking University)
Last. Jun-Yun Zhang (PKU: Peking University)H-Index: 14
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Purpose Dichoptic training is becoming a popular tool in amblyopia treatment. Here we investigated the effects of dichoptic demasking training in children with amblyopia who never received patching treatment (NPT group) or were no longer responsive to patching (PT group). Methods Fourteen NPT and thirteen PT amblyopes (6-16.5 years; 24 anisometropic, two strabismus, and one mixed) received dichoptic demasking training for 17 to 22 sessions. They used the amblyopic eye (AE) to practice contrast d...
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#1Chenyang Dai (SDU: Shandong University)H-Index: 2
#2Rao Me (WSU: Wayne State University)H-Index: 4
Last. Fu-Shin X. Yu (WSU: Wayne State University)H-Index: 38
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Purpose Interleukin (IL)-36 cytokines have been shown to play either beneficial or detrimental roles in the infection of mucosal tissues in a pathogen-dependent manner, but their involvement in fungal keratitis remains elusive. We herein investigated their expression and function in mediating corneal innate immunity against Candida albicans infection. Methods Gene expression in mouse corneas with or without C. albicans infection was determined by regular RT- and real-time (q)-PCR, Western blot a...
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#1John P. Kelly (UW: University of Washington)H-Index: 16
#2James O. Phillips (UW: University of Washington)H-Index: 19
Last. Avery H. Weiss (UW: University of Washington)H-Index: 24
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Purpose Children with cerebral visual impairment (CVI) often have abnormal visual orienting behaviors due to impaired or damaged visual cortex. Alternatively, visual-cortical function is intact but visual information is not transformed downstream into an appropriate oculomotor output (visuomotor dysfunction). We examined visual, anatomic, and oculomotor assessments to distinguish visuomotor dysfunction from CVI associated with severely reduced visual-cortical response. Methods We reviewed the me...
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#1Luca D'Onofrio (Sapienza University of Rome)H-Index: 10
#2Alise Kalteniece (University of Manchester)H-Index: 6
Last. Rayaz A. Malik (University of Manchester)H-Index: 64
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Purpose Increased corneal and epidermal Langerhans cells (LCs) have been reported in patients with diabetic neuropathy. The aim of this study was to quantify the density of LCs in relation to corneal nerve morphology and the presence of diabetic neuropathy and to determine if this differed in patients with type 1 diabetes mellitus (T1DM), type 2 diabetes mellitus (T2DM), and latent autoimmune diabetes of adults (LADA). Methods Patients with T1DM (n = 25), T2DM (n = 36), or LADA (n = 23) and cont...
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#1Cord Huchzermeyer (FAU: University of Erlangen-Nuremberg)H-Index: 7
#2Folkert K. Horn (FAU: University of Erlangen-Nuremberg)H-Index: 24
Last. Jan Kremers (FAU: University of Erlangen-Nuremberg)H-Index: 30
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Purpose The purpose of this study was to characterize summation of temporal L- and M-cone contrasts in the parvo- (P-) and magnocellular (M-) pathways in glaucoma and the relationship between the respective temporal contrast sensitivities (tCS) and clinical parameters. Methods Perifoveal tCS to isolated or combined L- and M-cone contrasts (with different contrast ratios, and therefore different luminance and chromatic components) were measured at different temporal frequencies (at 1 or 2 Hz and ...
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#1Joseph Collin (Newcastle University)H-Index: 14
#2Rachel Queen (Newcastle University)H-Index: 8
Last. Majlinda Lako (Newcastle University)H-Index: 49
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Purpose Retinoblastoma (Rb) is a malignant neoplasm arising during retinal development from mutations in the RB1 gene. Loss or inactivation of both copies of RB1 results in initiation of retinoblastoma tumors; however, additional genetic changes are needed for the continued growth and spread of the tumor. Ex vivo research has shown that in humans, retinoblastoma may initiate from RB1-depleted cone precursors. Notwithstanding, it has not been possible to assess the full spectrum of clonal types w...
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#1Bindu Kodati (University of North Texas Health Science Center)H-Index: 1
#2Dorota L. Stankowska (University of North Texas Health Science Center)H-Index: 16
Last. Raghu R. Krishnamoorthy (University of North Texas Health Science Center)H-Index: 21
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Purpose The goal of this study was to determine whether JNK2 played a causative role in endothelin-mediated loss of RGCs in mice. Methods JNK2-/- and wild type (C57BL/6) mice were intravitreally injected in one eye with 1 nmole of ET-1, whereas the contralateral eye was injected with the vehicle. At two time points (two hours and 24 hours) after the intravitreal injections, mice were euthanized, and phosphorylated c-Jun was assessed in retinal sections. In a separate set of experiments, JNK2-/- ...
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#1Anna Enzsoly (Semmelweis University)H-Index: 10
#2Rozina I. Hajdú (Semmelweis University)H-Index: 4
Last. Ákos Lukáts (Semmelweis University)H-Index: 13
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Purpose In diabetic subjects, early visual functional alterations such as color vision deficiencies (CVDs) are known to precede clinically apparent diabetic retinopathy. Prominent photoreceptor outer segment degeneration and an increase in the number of retinal dual cones (co-expressing S- and M-opsins simultaneously) have been described in diabetic rat models, suggesting a connection with the development of CVDs. As cone opsin expression is controlled by thyroid hormones, we investigated the di...
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#1Yao-Tseng WenH-Index: 6
#2Ching-Wen Huang (NTU: National Taiwan University)
Last. Rong-Kung Tsai (TCU: Tzu Chi University)H-Index: 17
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Purpose This study investigated the neuroprotective effects of administration of ROCK inhibitor E212 on ischemic optic neuropathy. Methods Rats received an intravitreal injection of either E212 or PBS immediately after optic nerve infarct. The oxidative stress in the retina was detected by performing superoxide dismutase activity and CellROX assays. The integrity of retinal pigment epithelium was determined by staining of zona occludens 1. The visual function, retinal ganglion cell (RGC) density...
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