Original paper
Pirfenidone inhibits macrophage infiltration in 5/6 nephrectomized rats
Abstract
Tubulointerstitial macrophage infiltration is a hallmark of chronic kidney disease involved in the progression of renal fibrosis. Pirfenidone is a newly identified antifibrotic drug, the potential mechanism of which remains unclear. The aim of this study was to investigate the effects of pirfenidone on M1/M2 macrophage infiltration in nephrectomized rats. Nephrectomized rats were treated with pirfenidone by gavage for 12 wk. Twenty-four hour...
Paper Details
Title
Pirfenidone inhibits macrophage infiltration in 5/6 nephrectomized rats
Published Date
Mar 15, 2013
Journal
Volume
304
Issue
6
Pages
F676 - F685
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Notes
History