Review paper
ATM and ATR as therapeutic targets in cancer
Abstract
In order to maintain genomic stability, cells have developed sophisticated signalling pathways to enable DNA damage or DNA replication stress to be resolved. Key mediators of this DNA damage response (DDR) are the ATM and ATR kinases, which induce cell cycle arrest and facilitate DNA repair via their downstream targets. Inhibiting the DDR has become an attractive therapeutic concept in cancer therapy, since (i) resistance to genotoxic therapies...
Paper Details
Title
ATM and ATR as therapeutic targets in cancer
Published Date
May 1, 2015
Journal
Volume
149
Pages
124 - 138
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