Development of a Nebulizer for a Sheathless Interfacing of NanoHPLC and ICPMS

A novel nebulizer (nDS-200) working at sample uptake rates of less than 500 nL min-1 was developed for a sheathless interfacing of nanoHPLC (75-μm column i.d.) with ICPMS. It was based on a hollow fused-silica needle of which the tip (i.d. 10 μm, o.d. 20 μm) centered in a 254-μm-i.d. sapphire orifice. The nebulizer, equipped with a 3-cm3 drain-free vaporization chamber, enabled a stable introduction into an ICP of aqueous mobile phases...