AB-OSEM reconstruction for improved Patlak kinetic parameter estimation: a simulation study

The non-negativity constraint inherently present in OSEM reconstruction successfully reduces the standard deviation in cold regions but at the cost of introducing a positive bias, especially at low iteration numbers. For low-count data, as often encountered in short-duration frames in dynamic imaging protocols, it has been shown that it can be advantageous (in terms of bias in the reconstructed image) to remove the non-negativity constraint. In...