Pharmacologic Induction of Posterior Vitreous Detachment in the Rabbit

• Objective.

—To assay the proteolytic activity of plasmin on the vitreoretinal junction and to assess a potential facilitating effect on posterior vitreous detachment.

Methods.

—We injected 1 U of plasmin into the vitreous of rabbits. Some eyes underwent vitrectomy after plasmin injection. Electroretinography and electron microscopy were performed.

Results.

—In plasmin-treated eyes, electroretinography displayed a...