Review paper
Cellular signaling by fibroblast growth factor receptors
Abstract
The 22 members of the fibroblast growth factor (FGF) family of growth factors mediate their cellular responses by binding to and activating the different isoforms encoded by the four receptor tyrosine kinases (RTKs) designated FGFR1, FGFR2, FGFR3 and FGFR4. Unlike other growth factors, FGFs act in concert with heparin or heparan sulfate proteoglycan (HSPG) to activate FGFRs and to induce the pleiotropic responses that lead to the variety of...
Paper Details
Title
Cellular signaling by fibroblast growth factor receptors
Published Date
Apr 1, 2005
Volume
16
Issue
2
Pages
139 - 149
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