Uncovering disease-disease relationships through the incomplete interactome
Abstract
A network approach to finding disease modules Shared genes represent a powerful but limited representation of the mechanistic relationship between two diseases. However, the analysis of protein-protein interactions has been hampered by the incompleteness of interactome maps. Menche et al. formulated the mathematical conditions needed to allow a disease module (a localized region of connections between disease-related proteins) to be observed....
Paper Details
Title
Uncovering disease-disease relationships through the incomplete interactome
Published Date
Feb 20, 2015
Journal
Volume
347
Issue
6224
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Notes
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