Nutrition-induced ketosis alters metabolic and signaling gene networks in liver of periparturient dairy cows

Dairy cows are highly susceptible after parturition to developing liver lipidosis and ketosis, which are costly diseases to farmers. A bovine microarray platform consisting of 13,257-annotated oligonucleotides was used to study hepatic gene networks underlying nutrition-induced ketosis. On day 5 postpartum, 14 Holstein cows were randomly assigned to ketosis-induction ( n = 7) or control ( n = 7) groups. Cows in the ketosis-induction group were...