Regulation of NF-κB-dependent gene expression by ligand-induced endocytosis of the interleukin-1 receptor
Abstract
Interleukin-1 (IL-1) induces the internalization of its cognate receptor from the plasma membrane. However, it has remained elusive as to how this mechanism affects the IL-1-induced signal transduction. In this study, we used small-molecule inhibitors of receptor endocytosis to analyze the effects on IL-1-induced signal transduction pathways. We demonstrate that the inhibition of endocytosis down-modulates IL-1-induced NF-κB-dependent gene...
Paper Details
Title
Regulation of NF-κB-dependent gene expression by ligand-induced endocytosis of the interleukin-1 receptor
Published Date
Jan 1, 2013
Journal
Volume
25
Issue
1
Pages
214 - 228
Citation AnalysisPro
You’ll need to upgrade your plan to Pro
Looking to understand the true influence of a researcher’s work across journals & affiliations?
- Scinapse’s Top 10 Citation Journals & Affiliations graph reveals the quality and authenticity of citations received by a paper.
- Discover whether citations have been inflated due to self-citations, or if citations include institutional bias.
Notes
History