Cellular Signalling
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#1Krysten E. Ferraino (NSU: Nova Southeastern University)H-Index: 1
#2Natalie Cora (NSU: Nova Southeastern University)H-Index: 1
Last. Anastasios Lymperopoulos (NSU: Nova Southeastern University)H-Index: 27
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Abstract Angiotensin II (AngII) uses two distinct G protein-coupled receptor (GPCR) types, AT1R and AT2R, to exert a plethora of physiologic effects in the body and to significantly affect cardiovascular homeostasis. Although not much is known about the signaling of the AT2R, AT1R signaling is known to be quite pleiotropic, mobilizing a variety of signal transducers inside cells to produce a biological outcome. When the outcome in question is aldosterone production from the adrenal cortex, the m...
1 CitationsSource
#1Rebecca Sohn (Goethe University Frankfurt)
#2Gundula Rösch (Goethe University Frankfurt)
Last. Zsuzsa Jenei-Lanzl (Goethe University Frankfurt)H-Index: 10
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Adrenoceptors (ARs) mediate the effects of the sympathetic neurotransmitters norepinephrine (NE) and epinephrine (E) in the human body and play a central role in physiologic and pathologic processes. Therefore, ARs have long been recognized as targets for therapeutic agents, especially in the field of cardiovascular medicine. During the past decades, the contribution of the sympathetic nervous system (SNS) and particularly of its major peripheral catecholamine NE to the pathogenesis of osteoarth...
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#1Samantha M. McNeill (Monash University)H-Index: 1
#2Jo-Anne Baltos (Monash University)H-Index: 11
Last. Lauren T. May (Monash University)H-Index: 28
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Adenosine modulates many aspects of human physiology and pathophysiology through binding to the adenosine family of G protein-coupled receptors, which are comprised of four subtypes, the A1R, A2AR, A2BR and A3R. Modulation of adenosine receptor function by exogenous agonists, antagonists and allosteric modulators can be beneficial for a number of conditions including cardiovascular disease, Parkinson's disease, and cancer. Unfortunately, many preclinical drug candidates targeting adenosine recep...
1 CitationsSource
#1Tamotsu Tsukahara (Nagasaki University)H-Index: 17
#2Yasuka Sahara (Nagasaki University)
Last. Kimiko Murakami-Murofushi (Ochanomizu University)H-Index: 28
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Abstract Lipid-protein interactions play essential roles in many biological phenomena. Lysophospholipid mediators, such as cyclic phosphatidic acid (cPA), have been recognized as secondary messengers, yet few cellular targets for cPA have been identified to date. Furthermore, the molecular mechanism that activates these downstream signaling events remains unknown. In this study, using metabolically stabilized cPA carba-derivative (2ccPA)-immobilized magnetic beads, we identified adenine nucleoti...
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#1Shujing Li (DUT: Dalian University of Technology)H-Index: 8
#2Wanping Guo (DUT: Dalian University of Technology)
Last. Huijian Wu (DUT: Dalian University of Technology)H-Index: 17
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Abstract Apoptosis is an evolutionarily conserved form of programed cell death (PCD) that has a vital effect on early embryonic development, tissue homeostasis and clearance of damaged cells. Dysregulation of apoptosis can lead to many diseases, such as Alzheimer's disease, cancer, AIDS and heart disease. The anti-apoptotic protein MCL1, a member of the BCL2 family, plays important roles in these physiological and pathological processes. Its high expression is closely related to drug resistances...
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#1Xinrong Zhang (HAU: Huazhong Agricultural University)
#2Xiao-Lin Chen (HAU: Huazhong Agricultural University)
Abstract The ubiquitin related modifier Urm1 protein was firstly identified in the yeast Saccharomyces cerevisiae, and was later found to play important roles in different eukaryotes. By the assistance of an E1-like activation enzyme Uba4, Urm1 can function as a modifier to target proteins, called urmylation. The thioredoxin peroxidase Ahp1 was the only identified Urm1 target in the early time. Recently, many other Urm1 targets were identified, which is important for us to fully understand funct...
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#1Graciela Pineyro (UdeM: Université de Montréal)H-Index: 27
#2Karim Nagi (Qatar University)H-Index: 8
Abstract Opioid analgesics are elective for treating moderate to severe pain but their use is restricted by severe side effects. Signaling bias has been proposed as a viable means for improving this situation. To exploit this opportunity, continuous efforts are devoted to understand how ligand-specific modulations of receptor functions could mediate the different in vivo effects of opioids. Advances in the field have led to the development of biased agonists based on hypotheses that allocated de...
1 CitationsSource
#1Arzu Ulu (UCI: University of California, Irvine)
#1Arzu Ulu (University of Texas Health Science Center at Houston)H-Index: 18
Last. Jeffrey A. Frost (University of Texas Health Science Center at Houston)H-Index: 20
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Abstract The Neuroepithelial transforming gene 1 (Net1) is a RhoA subfamily guanine nucleotide exchange factor that is overexpressed in a number of cancers and contributes to cancer cell motility and proliferation. Net1 also plays a Rho GTPase independent role in mitotic progression, where it promotes centrosomal activation of Aurora A and Pak2, and aids in chromosome alignment during prometaphase. To understand regulatory mechanisms controlling the mitotic function of Net1, we examined whether ...
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#1Alexandra M. Garvin (UA: University of Arizona)
#2Bilal S. Khokhar (UA: University of Arizona)
Last. Taben M. Hale (UA: University of Arizona)H-Index: 15
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Abstract Angiotensin II (Ang II) is a primary mediator of profibrotic signaling in the heart and more specifically, the cardiac fibroblast. Ang II-mediated cardiomyocyte hypertrophy in combination with cardiac fibroblast proliferation, activation, and extracellular matrix production compromise cardiac function and increase mortality in humans. Profibrotic actions of Ang II are mediated by increasing production of fibrogenic mediators (e.g. transforming growth factor beta, scleraxis, osteopontin,...
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#1Wujun Li (Xi'an Jiaotong University)
Last. Yi Yang (Xi'an Jiaotong University)
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Abstract Tumor cells switch from an epithelial to a mesenchymal-like phenotype, which represents a key hallmark of human cancer metastasis, including gallbladder cancer (GBC). A large set of microRNAs (miRNAs/miRs) have been studied to elucidate their functions in initiating or inhibiting this phenotypic switching in GBC cells. In this paper, we attempted to identify the expression pattern of the miR-214/−3120 cluster and its mode of action in the context of GBC, with a specific focus being plac...
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