On the pre-clinical validation of a commercial model-based optimisation engine: Application to volumetric modulated arc therapy for patients with lung or prostate cancer

Purpose To evaluate the performance of a model-based optimisation process for volumetric modulated arc therapy applied to advanced lung cancer and to low risk prostate carcinoma patients. Methods and materials Two sets each of 27 previously treated patients, were selected to train models for the prediction of dose–volume constraints. The models were validated on the same sets of plans (closed-loop) and on further two sets each of 25 patients not...