Triterpenoids isolated from apple peels have potent antiproliferative activity and may be partially responsible for apple's anticancer activity.

Published on May 8, 2007in Journal of Agricultural and Food Chemistry4.192
· DOI :10.1021/JF063563O
Xiangjiu He12
Estimated H-index: 12
(Cornell University),
Rui Hai Liu79
Estimated H-index: 79
Sources
Abstract
Bioactivity-guided fractionation of apple peels was used to determine the chemical identity of bioactive constituents. Thirteen triterpenoids were isolated, and their chemical structures were identified. Antiproliferative activities of the triterpenoids against human HepG2 liver cancer cells, MCF-7 breast cancer cells, and Caco-2 colon cancer cells were evaluated. Most of the triterpenoids showed high potential anticancer activities against the three human cancer cell lines. Among the compounds isolated, 2α-hydroxyursolic acid, 2α-hydroxy-3β-{[(2E)-3-phenyl-1-oxo-2-propenyl]oxy}olean-12-en-28-oic acid, and 3β-trans-p-coumaroyloxy-2α-hydroxyolean-12-en-28-oic acid showed higher antiproliferative activity toward HepG2 cancer cells. Ursolic acid, 2α-hydroxyursolic acid, and 3β-trans-p-coumaroyloxy-2α-hydroxyolean-12-en-28-oic acid exhibited higher antiproliferative activity against MCF-7 cancer cells. All triterpenoids tested showed antiproliferative activity against Caco-2 cancer cells, especially 2α-hydrox...
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