Large vessel vasculitis with myelodysplastic syndrome.

Published on Jan 1, 2014in Internal Medicine1.005
· DOI :10.2169/INTERNALMEDICINE.53.0949
Takayuki Katsuyama10
Estimated H-index: 10
(Okayama University),
Haruhito A. Uchida15
Estimated H-index: 15
(Okayama University)
+ 5 AuthorsHirofumi Makino98
Estimated H-index: 98
(Okayama University)
A 71-year-old woman presented with a high-grade fever, neck pain, anemia and thrombocytopenia. After performing further examinations, we concluded that she had simultaneously developed large vessel vasculitis and myelodysplastic syndrome (MDS). Although glucocorticoid administration improved her clinical symptoms, the MDS transformed into acute myeloid leukemia and she died one year after receiving the diagnosis. The occurrence of immune-mediated disorders in patients with MDS is a well-known phenomenon; however, large vessel vasculitis is a rare complication of MDS. Our case suggests that the association between systemic vasculitis and MDS may result in poor outcomes.
#1Cloé ComarmondH-Index: 24
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Last. David Saadoun (UPMC: Pierre-and-Marie-Curie University)H-Index: 73
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Abstract Takayasu arteritis (TA) is a rare large vessels vasculitis. Conventional therapy consists of glucocorticoids which may be associated with other immunosuppressive drugs. However, some patients fail to achieve remission with conventional treatment. The use of anti-tumor necrosis factor-α (TNF-α) in patients with difficult to treat TA could be useful. We report here the main characteristics, treatment and outcome of 84 patients (5 personal cases and 79 patients from the literature) with re...
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#2Go Haraguchi (Tokyo Medical and Dental University)H-Index: 19
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#2Anat Shyman (HUJI: Hebrew University of Jerusalem)H-Index: 1
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