A Combination Drug Treatment Against Ocular Sulfur Mustard Injury

Published on Jan 1, 2005in Journal of Toxicology-cutaneous and Ocular Toxicology
· DOI :10.1081/CUS-120027483
Michael C. Babin12
Estimated H-index: 12
(United States Army Medical Research Institute of Chemical Defense),
Karen M. Ricketts6
Estimated H-index: 6
(United States Army Medical Research Institute of Chemical Defense)
+ 3 AuthorsJohn J. Brozetti1
Estimated H-index: 1
Sources
Abstract
The eye is considered to be one of the most sensitive organs to sulfur mustard [bis(2‐chloroethyl) sulfide (SM)], with injuries ranging from mild conjunctivitis to advanced corneal disease. Even mild ocular involvement from sulfur mustard exposure can result in both physical and psychological incapacitation. In this study we explored the use of Food and Drug Administration (FDA) approved medications (prednisolone acetate ophthalmic suspension, triamcinolone, and cefazolin) as ocular treatments for sulfur mustard injury. Female New Zealand White rabbits were divided into a SM positive control group (n = 8) and a single treatment group (n = 7). At 10, 20, 30, 60, 90, and 120 min after SM exposure, two drops of prednisolone acetate ophthalmic suspension was administered to each treatment group rabbit while the control group received saline drops. At 120 min after SM exposure, each treatment group animal received a single 1.0 mL sub‐Tenon's injection containing 20 mg triamcinolone and 50 mg cefazolin. Control...
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