Modeling pO2 Distributions in the Bone Marrow Hematopoietic Compartment. I. Krogh's Model

Human bone marrow (BM) is a tissue of complex architectural organization, which includes granulopoietic loci, erythroblastic islets, and lymphocytic nodules. Oxygen tension (pO2) is an important determinant of hematopoietic stem and progenitor cell proliferation and differentiation. Thus, understanding the impact of the BM architectural organization on pO2 levels in extravascular hematopoietic tissue is an important biophysical problem. However,...