Wip1 deficiency impairs haematopoietic stem cell function via p53 and mTORC1 pathways

Zhiyang Chen; Weiwei Yi; Yohei Morita; Hu Wang; Yu-Sheng Cong; Jun-Ping Liu; Zhi-Cheng Xiao; K. Lenhard Rudolph; Tao Cheng Cheng; Zhenyu Ju

doi:https://doi.org/10.1038/ncomms7808

doi.org/10.1038/ncomms7808

Wip1 deficiency impairs haematopoietic stem cell function via p53 and mTORC1 pathways

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..., Zhenyu Ju

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Nature Communications16.60

Volume: 6, Issue: 1

Published: Apr 16, 2015

Abstract

Wild-type p53-induced phosphatase 1 (Wip1) negatively regulates several tumour suppressor and DNA damage response pathways. However, the impact of Wip1 on haematopoietic stem cell (HSC) homeostasis and aging remains unknown. Here we show that Wip1 is highly expressed in HSCs but decreases with age. Wip1-deficient (Wip1(-/-)) mice exhibited multifaceted HSC aging phenotypes, including the increased pool size and impaired repopulating activity....

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Paper Details

Title

Wip1 deficiency impairs haematopoietic stem cell function via p53 and mTORC1 pathways

DOI

doi.org/10.1038/ncomms7808

Published Date

Apr 16, 2015

Journal

Nature Communications

Volume

6

Issue

1

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