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Biochemistry and molecular cell biology of diabetic complications
Abstract
Diabetes-specific microvascular disease is a leading cause of blindness, renal failure and nerve damage, and diabetes-accelerated atherosclerosis leads to increased risk of myocardial infarction, stroke and limb amputation. Four main molecular mechanisms have been implicated in glucose-mediated vascular damage. All seem to reflect a single hyperglycaemia-induced process of overproduction of superoxide by the mitochondrial electron-transport...
Paper Details
Title
Biochemistry and molecular cell biology of diabetic complications
Published Date
Dec 13, 2001
Journal
Volume
414
Issue
6865
Pages
813 - 820
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