Tumor growth in experimental animals. Nutritional manipulation and chemotherapeutic response in the rat.

Published on Mar 1, 1980in Annals of Surgery12.969
路 DOI :10.1097/00000658-198003000-00010
Brian J. Rowlands59
Estimated H-index: 59
Sources
Abstract
The effects of nutritional manipulation on host body weight dynamics, tumor growth patterns and host-tumor responses to chemotherapy were studied in Sprague-Dawley rats with Walker-256 carcinosarcomas. Group I maintained throughout on a regular diet (RD) gained carcass weight steadily. Group II lost carcass weight while fed a protein-free diet (PFD) but rapidly gained weight after switching to RD on day 15. Mean tumor volume increased 105% in Group I from day 15 to 21, 218% in Group II and 77% in Group III (continued on PFD p less than 0.05). From day 21 to day 33 tumor growth patterns were similar in Groups I and II, while mean tumor volume eventually plateaued in Group III. In Study B, Group II animals were given Methotrexate (MTX-20 mg/kg) two days and six days after switching from PFD to RD. The mean change in tumor volume in the MTX-treated rats was 1.31 +/- 0.1 cm3 compared with 8.14 +/- 0.1 cm3 (p less than 0.001) in the saline-treated control rats. MTX did not significantly affect tumor growth patterns in Group III (PFD) rats. In Study A, protein-calorie malnutrition resulted in host carcass weight loss and tumor growth retardation while nutritional repletion restored host carcass weight and stimulated tumor growth. In Study B, MTX was maximally effective in tumor-bearing rats that were switched from PFD to RD demonstrating that nutritional manipulation can improve host nutritional status and increase tumor response to chemotherapy.
馃摉 Papers frequently viewed together
19806.86Cancer
19783.98Surgery
References0
Newest
Cited By53
Newest
#1Alejandro P茅rez-Pitarch (University of Valencia)H-Index: 7
#2Beatriz Guglieri-L贸pez (University of Valencia)H-Index: 6
Last. Matilde Merino-Sanju谩n (University of Valencia)H-Index: 17
view all 5 authors...
ABSTRACTThe etiology of undernourishment in cancer patients is multifactorial: tumor-related mechanisms (such as obstruction, metabolic abnormalities, and functionality changes) in addition to the influence of anticancer therapies, which can induce or worsen undernutrition. The evident role of undernutrition in cancer treatment outcomes suggests the need of considering nutritional status when evaluating anticancer drugs. In order to merge the available data and offer researchers and clinicians a...
Source
#1Edward M. Copeland (UF: University of Florida)H-Index: 76
#2Jose M. PimientoH-Index: 21
Last. Stanley J. Dudrick (Yale University)H-Index: 33
view all 3 authors...
Before 1972, total parenteral nutrition (TPN) was used sparingly in patients with cancer for fear of stimulating tumor growth or inducing septicemia via the indwelling subclavian catheters. The immune incompetence and the infectious consequences of malnutrition have been well characterized since that time. As a fellow in surgical oncology at the University of Texas MD Anderson Hospital (MDAH) in 1971, the first author of this article (Dr Copeland) observed that there often were patients who were...
Source
#1Maurizio Bossola (UCSC: Catholic University of the Sacred Heart)H-Index: 47
#2Fabio Pacelli (UCSC: Catholic University of the Sacred Heart)H-Index: 31
Last. Giovan Battista Doglietto (UCSC: Catholic University of the Sacred Heart)H-Index: 13
view all 5 authors...
Many studies have been conducted to ascertain if nutrition support (NS), either as parenteral nutrition (PN) or enteral nutrition (EN), stimulates tumor growth and causes cancer progression, but after almost 30 years, the question remains at least in part unresolved. In this study, previous studies were reviewed to evaluate the effect of NS on tumor growth, tumor proliferation, tumor apoptosis, and cancer-related survival in humans. MEDLINE and PubMed were searched using combinations of the foll...
Source
Summary Background & aims Although there is an experimental evidence that intravenous administration of nutrients may increase tumour growth in animals, data on humans are scanty and sparse. The purpose of this study was to review the literature that has specifically investigated the effects of nutritional support on tumour growth in cancer patients. Methods A review of the literature identified 12 suitable papers representing a total of 140 patients receiving nutritional support versus 84 contr...
Source
Source
#1Ricardo J. Komotar (Columbia University)H-Index: 65
#2Brad E. Zacharia (Columbia University)H-Index: 32
Last. E. Sander Connolly (Columbia University)H-Index: 89
view all 4 authors...
THE MANAGEMENT OF unruptured cerebral aneurysms remains one of the most controversial topics in neurosurgery. To this end, we discuss the diagnosis and estimated prevalence of these lesions as well as review the literature regarding the rate of rupture for cerebral aneurysms and risks of operative intervention. Our interpretation of the literature concludes that aneurysms are present in approximately 1% of the adult population, varying between less than 1% in young adults to 4% in the elderly. T...
Source
#1Lawrence E. Harrison (RU: Rutgers University)H-Index: 29
Cancer cachexia is a complex syndrome clinically manifest by progressive involuntary weight loss and diminished food intake and characterized by a variety of biochemical alterations. Importantly, cancer cachexia has been associated with increased morbidity and mortality and decreased response to therapy. The impact of cancer cachexia on patient outcome and healthcare resources continues to be significant. It is therefore important to identify those cancer patients who are malnourished in an atte...
Source
#1Thomas O. Rumley (UF: University of Florida)H-Index: 5
#2Edward M. Copeland (UF: University of Florida)H-Index: 76
Debilitating cancer cachexia is multifactorial, but many of the etiologies and most of the resulting effects are similar to those seen in malnourished patients without cancer. From the work in human beings and experimental animals, nutritional support of the tumor-bearing host can replenish lean body mass, visceral protein components, and immunocompetence. This induction of anabolism, however, depends on time, content, the method of administration of hyperalimentation solutions; the initial and ...
Source
#1Manabu Okuyama (Akita University)H-Index: 12
#2Satoru Motoyama (Akita University)H-Index: 25
Last. Jun-ichi Ogawa (Akita University)H-Index: 28
view all 8 authors...
Purpose The mechanism underlying the immunomodulation caused by blood transfusion has yet to be elucidated. The aim of the present study was to determine whether the transfusion of a soluble or insoluble factor present in stored blood can induce immunomodulation, which would thereby promote solid tumor growth.
Source
#1M. L. Da Costa (RCSI: Royal College of Surgeons in Ireland)H-Index: 5
#2Henry Paul Redmond (RCSI: Royal College of Surgeons in Ireland)H-Index: 59
Last. David Bouchier-Hayes (RCSI: Royal College of Surgeons in Ireland)H-Index: 68
view all 5 authors...
Background Surgery depresses host tumoricidal activity and may increase tumour growth. This study compared the effects of laparoscopy with laparotomy on extraperitoneal tumour growth and immune function in a murine model. Methods C57BL/6 female mice aged 8鈥10 weeks had tumours induced in the right flank (n = 45) and were randomized to undergo halothane anaesthesia only, laparoscopy or laparotomy. Flank tumour volume was assessed over 10 days. A second group of animals (n = 540) were randomized t...
Source
This website uses cookies.
We use cookies to improve your online experience. By continuing to use our website we assume you agree to the placement of these cookies.
To learn more, you can find in our Privacy Policy.