Original paper

IL-4 induces IL-13–independent allergic airway inflammation

Volume: 118, Issue: 2, Pages: 410 - 419
Published: Aug 1, 2006
Abstract
The related T(H)2 cytokines IL-4 and IL-13 are produced during allergic responses, signal through receptors that contain IL-4 receptor (IL-4R) alpha, and promote allergic inflammation by activating signal transducer and activator of transcription 6. IL-4 promotes T(H)2 response induction, and IL-13 is necessary and sufficient to induce airways hyperresponsiveness (AHR) and goblet cell hyperplasia in some mouse models of asthma. The nonredundant...
Paper Details
Title
IL-4 induces IL-13–independent allergic airway inflammation
Published Date
Aug 1, 2006
Volume
118
Issue
2
Pages
410 - 419
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