The Hsp90 Chaperone Machinery Regulates Signaling by Modulating Ligand Binding Clefts

In the two decades that have elapsed since the molecular chaperone Hsp90 2The abbreviations used are:Hspheat shock proteinE3ubiquitin-protein isopeptide ligaseCHIPC terminus of Hsc70-interacting proteinLBDligand binding domainGRglucocorticoid receptorHopHsp-organizing proteinTPRtetratricopeptide repeatHDAChistone deacetylasenNOSneuronal nitric-oxide synthase. 2The abbreviations used are:Hspheat shock proteinE3ubiquitin-protein isopeptide...