Protective action of the serine protease inhibitorN-tosyl-L-lysine chloromethyl ketone (TLCK) against acute soman poisoning

Soman‐poisoned rats display cholinergic crisis, a systemic mast cell degranulation characteristic of anaphylactic reactions and an excitotoxin‐like sequential seizure and neuronal degeneration. The protection of guinea pigs from soman lethality by prophylactic administration of the serine protease inhibitor suramin suggests a possible proteolytic component in soman poisoning. The present study tested the effect of N ‐tosyl‐ L ‐lysine...