Journal of Applied Toxicology
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3.45
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4,111
Papers 4,053
1 page of 406 pages (4,053 results)
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Phospholipases are used extensively in the production of food ingredients, typically as processing aids, to enzymatically convert glycerophospholipids and provide functional properties in meat products or baking confections. The current study examined the safety of Phospholipase D derived from Kitasatospora paracochleata (strain No. 362-PLD) for use as a processing aid in various food applications, where it may be present in the finished products at trace levels. The safety assessment of Phospho...
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#1Ryota Ojiro (TUAT: Tokyo University of Agriculture and Technology)H-Index: 3
#2Yousuke Watanabe (TUAT: Tokyo University of Agriculture and Technology)H-Index: 6
Last. Makoto Shibutani (TUAT: Tokyo University of Agriculture and Technology)H-Index: 23
view all 12 authors...
We have previously reported that the valproic acid (VPA)-induced disruption pattern of hippocampal adult neurogenesis differs between developmental and 28-day postpubertal exposure. In the present study, we performed brain region-specific global gene expression profiling to compare the profiles of VPA-induced neurotoxicity between developmental and postpubertal exposure. Offspring exposed to VPA at 0, 667, and 2000 parts per million (ppm) via maternal drinking water from gestational day 6 until ...
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#1Yukio KawashimaH-Index: 7
#2Yuta OnishiH-Index: 1
Last. Taisen Iguchi (YCU: Yokohama City University)H-Index: 29
view all 14 authors...
In June 2016, the Ministry of the Environment of Japan announced a program "EXTEND2016" on the implementation of testing and assessment for endocrine active chemicals, consisting of a two-tiered strategy. The aim of the Tier 1 screening and the Tier 2 testing is to identify the impacts on the endocrine system and to characterize the adverse effects to aquatic animals by endocrine disrupting chemicals detected in the aquatic environment in Japan. For the consistent assessment of the effects on re...
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#1Ishfaq A. Sheikh (KAU: King Abdulaziz University)H-Index: 13
#2Mohd A. Beg (KAU: King Abdulaziz University)H-Index: 45
The human exposure to diverse endocrine-disrupting chemicals (EDCs) has increased dramatically over several decades with very adverse health effects. Plasticizers and flame retardants constitute important classes of EDCs interfering in endocrine physiology including the thyroid function. Thyroxine (T4) is an important hormone regulating metabolism and playing key roles in developmental processes. In this study, six phthalate and nonphthalate plasticizers and one flame retardant (BDE-153) were su...
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#1Hanne Bendiksen Skogvold (Oslo University Hospital)
#2Mazyar Yazdani (Oslo University Hospital)H-Index: 9
Last. Katja Benedikte Prestø Elgstøen (Oslo University Hospital)H-Index: 7
view all 8 authors...
The neurotoxin 3-nitropropionic acid (3-NPA) is an inhibitor of succinate dehydrogenase, an enzyme participating both in the citric acid cycle and the mitochondrial respiratory chain. In human intoxications, it produces symptoms such as vomiting and stomach ache in mild cases, and dystonia, coma, and sometimes death in severe cases. We report the results from a liquid chromatography-Orbitrap mass spectrometry metabolomics study mapping the metabolic impacts of 3-NPA intoxication in plasma, urine...
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#1Lindsay E. Brown (KSU: Kennesaw State University)
#2Giovanni Reyes (KSU: Kennesaw State University)
Last. Eric A. Albrecht (KSU: Kennesaw State University)H-Index: 7
view all 3 authors...
Understanding the mechanisms that produce cellular cytotoxicity is fundamental in the field of toxicology. Cytotoxic stimuli can include organic toxins such as hemorrhagic snake venom, which can lead to secondary complications such as the development of necrotic tissue and profuse scarring. These clinical manifestations mimic cytotoxic responses induce by other organic compounds such as organic acids. We used hemorrhagic snake venom and human embryonic kidney cells (HEK 293T) as a model system t...
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#1Hongrui Geng (SCAU: South China Agricultural University)
#2Xiaotong Tan (SCAU: South China Agricultural University)H-Index: 6
Last. Yugu Li (SCAU: South China Agricultural University)H-Index: 10
view all 5 authors...
Zearalenone (ZEA) is one of the most major food contaminants in cereal crops worldwide, risking health of both livestock and humans. This study aimed to assess the cytotoxicity and the underlying mechanism of ZEA on thymic epithelial cells. By using proteomics analysis, we identified 596 differentially expressed proteins in MTEC1 cells upon zearalenone exposure, of which 245 were upregulated and 351 were downregulated. Gene ontology (GO) analysis suggested that differentially expressed proteins ...
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#1Lingyue Zou (SEU: Southeast University)H-Index: 7
#2Lilin Xiong (CDC: Centers for Disease Control and Prevention)H-Index: 3
Last. Meng Tang (SEU: Southeast University)H-Index: 33
view all 11 authors...
Fine particulate matter (PM2.5 )-induced detrimental cardiovascular effects have been widely concerned, especially for endothelial cells, which is the first barrier of the cardiovascular system. Among potential mechanisms involved, reactive oxidative species take up a crucial part. However, source of oxidative stress and its relationship with inflammatory response have been rarely studied in PM2.5 -induced endothelial injury. Here, as a key oxidase that catalyzes redox reactions, NADPH oxidase (...
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Ischemic heart disease is the leading cause of cardiovascular mortality, which is related to cardiac myocyte apoptosis. Butorphanol is an opioid receptor agonist with potential cardioprotective function. The purpose of this work is to explore the function and mechanism of butorphanol in oxygen and glucose deprivation/reperfusion (OGD/R)-induced cardiomyocyte apoptosis. The overlapping targets of ischemic heart disease and butorphanol were analyzed according to GeneCards, ParmMapper, Cytoscape, a...
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#2Zhenzhen Tan (HMU: Hebei Medical University)
Last. Huicai Guo (HMU: Hebei Medical University)H-Index: 10
view all 10 authors...
Doxorubicin (DOX)-induced cardiotoxicity impedes its clinical application, but the mechanisms have not been thoroughly elucidated. Based on circRNA and mRNA expression profiles, we illustrated RNA expression signature changes during DOX-induced cardiotoxicity; mechanism exploration and biomarkers screening were also conducted. Twelve mice were randomly divided into two groups, induction group was treated with doxorubicin, and the control group was given an equal quantity of saline. After the con...
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