Intrathecal IgM‐synthesis does not correlate with the risk of relapse in patients with a primary demyelinating event

The objective of this study was to investigate, whether the presence of oligoclonal immunoglobulin M bands (IgM‐OCB) in cerebrospinal fluid (CSF) from patients with a clinically isolated syndrome (CIS), which is suggestive for the first clinical manifestation of multiple sclerosis (MS), anticipates the risk of a relapse during a retrospective study period of 21–106 months (mean 60 ± 25). A relapse would lead to the diagnosis of clinically...