Original paper
Cbfa-1 mediates nitric oxide regulation of MMP-13 in osteoblasts
Abstract
During bone development, osteoblast differentiation requires remodeling of the extracellular matrix. Although underlying mechanisms have not been elucidated, evidence points to the participation of the nitric oxide (NO) and cyclic guanosine 3′,5′-monophosphate (cGMP) system. Here, we detected increased matrix metalloproteinase (MMP)-13 mRNA, protein and activity, as well as increased inducible NO synthase (iNOS) and NO production during the...
Paper Details
Title
Cbfa-1 mediates nitric oxide regulation of MMP-13 in osteoblasts
Published Date
May 1, 2006
Journal
Volume
119
Issue
9
Pages
1896 - 1902
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Notes
History