Adipose-Derived Stems Cells and Their Role in Human Cancer Development, Growth, Progression, and Metastasis: A Systematic Review

Published on Apr 1, 2015in Cancer Research9.727
· DOI :10.1158/0008-5472.CAN-14-2744
Kyle E. Freese6
Estimated H-index: 6
(University of Pittsburgh),
Lauren E. Kokai14
Estimated H-index: 14
(University of Pittsburgh)
+ 7 AuthorsFaina Linkov20
Estimated H-index: 20
(University of Pittsburgh)
Obesity is a well recognized risk factor for several types of cancers, many of which occur solely or disproportionately in women. Adipose tissue is a rich source of adipose-derived stem cells (ASC), which have received attention for their role in cancer behavior. The purpose of this systematic review is to present the existing literature on the role of ASCs in the growth, development, progression, and metastasis of cancer, with an emphasis on malignancies that primarily affect women. To accomplish this goal, the bibliographic database PubMed was systematically searched for articles published between 2001 and 2014 that address ASCs9 relationship to human cancer. Thirty-seven articles on ASCs9 role in human cancer were reviewed. Literature suggests that ASCs exhibit cancer-promoting properties, influence/are influenced by the tumor microenvironment, promote angiogenesis, and may be associated with pathogenic processes through a variety of mechanisms, such as playing a role in hypoxic tumor microenvironment. ASCs appear to be important contributors to tumor behavior, but research in areas specific to women9s cancers, specifically endometrial cancer, is scarce. Also, because obesity continues to be a major health concern, it is important to continue research in this area to improve understanding of the impact adiposity has on cancer incidence. Cancer Res; 75(7); 1161–8. ©2015 AACR .
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