As the congenital heart disease population ages, coronary artery disease may emerge as a significant comorbidity. This presents a new problem to cardiologists caring for an aging population that did not previously exist. Various congenital heart defects are likely at higher risk for the development of coronary artery disease including congenital coronary artery anomalies, defect with abnormal coronary artery connections to the ventricles, and conotruncal anomalies that require coronary artery reimplantation. The impact of coronary artery disease on this population remains to be seen.
Last. Younes Boudjemline(Paris V: Paris Descartes University)H-Index: 46
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Objectives Evaluate the incidence, diagnosis, and outcome of coronary compression (CC) during right-ventricular outflow tract interventions. Background The incidence, risk factors, diagnosis, and outcomes of CC during percutaneous pulmonary valve implantation are poorly defined. Methods One-hundred consecutive patients (May 2008 to January 2012) undergoing transcatheter right-ventricular outflow tract treatment in two institutions were studied. Results CC occurred in six patients (6%) with a rig...
Last. David R. Weber(Children's Hospital of Philadelphia)H-Index: 16
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Background Anomalous aortic origin of a coronary artery with an interarterial and intramural course (AAOCA) is a rare anomaly with increased risk of sudden cardiac death during or just after exercise among otherwise healthy youth. Risk stratification and management remain controversial, especially for the asymptomatic child with an anomalous right coronary artery from the left coronary sinus (ARCA). Medium-term surgical and quality-of-life (QOL) outcome data are lacking in this population. Metho...
Aims The population of adults with congenital heart disease (ACHD) is growing and ageing. Limited information about the diagnostic spectrum of this emerging population, its resource utilization at tertiary ACHD centres, and especially about prognostic parameters is available. Methods and results Retrospective cohort study on all ACHD patients ≥60 years of age under active follow-up. All-cause mortality was the primary outcome measure. Out of a total population of 7315 ACHD patients, 375 [190 fem...
Abstract Obesity, hypertension, and coronary artery disease are prevalent in the general population and well recognized as contributors to cardiac morbidity and mortality. With surgical and medical advances, there is a growing and aging population with congenital heart disease who are also at risk of developing these comorbidities. In addition, some congenital cardiac lesions predispose patients to conditions such as hypertension or coronary artery disease. The effect of these comorbidities on t...
#2Rocío Castilla(CONICET: National Scientific and Technical Research Council)H-Index: 13
Last. José Milei(CONICET: National Scientific and Technical Research Council)H-Index: 29
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Abstract Background Congenital heart defects or the process of their repair leads to an increased risk for adult cardiovascular disease compared with the general population. Intimal hyperplasia is a preatherosclerotic lesion that may be produced as a consequence of transforming growth factor β1 (TGF-β1) pathway activation. We studied the presence of intimal hyperplasia in arteries from a pediatric population with congenital heart disease (CHD) and TGF-β1 expression to enlighten its possible role...
Last. Jarrod D. Knudson(UMMC: University of Mississippi Medical Center)H-Index: 19
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Expanded surgical options and improved outcomes for children born with structural heart defects have ushered a greater clinical interest in the normal and abnormal development of the coronary circulation. Anatomic variations of the coronary system may impact surgical candidacy or operative technique during neonatal life, while others may impact long-term clinical management and planning for subsequent interventions. This review aims to characterize coronary artery anatomy in symptomatic congenit...
Abstract Background There are now more adults with congenital heart disease than children. This aging cohort is at risk for acquired heart diseases such as coronary artery disease (CAD). The purpose of the study was to examine the clinical features of the CAD in adults with congenital heart disease. Methods A retrospective chart review was performed. The clinical characteristics of adults with congenital heart disease and angiographically confirmed atherosclerotic CAD were examined. Results One ...
Last. John E. Mayer(Boston Children's Hospital)H-Index: 121
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Background—Data regarding long-term outcomes after the arterial switch operation for D-transposition of the great arteries are scarce. Methods and Results—A single-institution retrospective cohort study was conducted to assess cardiovascular outcomes after an arterial switch operation between 1983 and 1999. Patients without follow-up visits within 3 years were contacted and secondary sources of information obtained. Overall, 400 patients, 154 (38.3%) with a ventricular septal defect, 238 (59.5%)...
Last. Amy L. Juraszek(Children's Medical Center of Dallas)H-Index: 17
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Objectives Aortic atresia (AA) in hypoplastic left heart syndrome (HLHS) has been associated with increased mortality in several prior studies. We reviewed our autopsy series to explore the relationship of coronary abnormalities to anatomic subsets of HLHS with AA. Methods We retrospectively reviewed all pathology specimens with AA/MS (mitral stenosis) and AA/MA (mitral atresia) in the Cardiac Registry of Children's Hospital Boston between 1955 and 2009 including autopsy reports, operative notes...
Objective For infants with single ventricle malformations undergoing staged repair, interstage mortality is reported at 2% to 20%. The Single Ventricle Reconstruction trial randomized subjects with a single morphologic right ventricle undergoing a Norwood procedure to a modified Blalock–Taussig shunt (MBTS) or a right ventricle-to-pulmonary artery shunt (RVPAS). The aim of this analysis was to explore the associations of interstage mortality and shunt type, and demographic, anatomic, and periope...
While women are under-represented in research on cardiovascular disease (CVD), little is known about the attitudes of men and women with CVD regarding participation in clinical research studies/clinical trials. Patients with CVD (and/or risk factors) and patients with other chronic conditions from Iowa were recruited from a commercial panel. An on-line survey assessed willingness to participate (WTP) and other attitudes towards aspects of clinical research studies. Based on 504 respondents, ther...
Last. Nicolas L Madsen(Cincinnati Children's Hospital Medical Center)H-Index: 11
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We compared the incidence and 30-day mortality of myocardial infarction (MI) in adults with congenital heart disease (CHD) relative to the general population. This cohort study used nationwide population-based medical databases to identify individuals born before 1982 and diagnosed with CHD in Denmark between 1963 and 2012. Patients were followed for first-time MI using data from the Danish National Registry of Patients. For each subject with CHD, we identified 10 controls from the general popul...
#1Angela Rao(UTS: University of Technology, Sydney)H-Index: 4
#2Louise D. Hickman(UTS: University of Technology, Sydney)H-Index: 15
Last. David Sibbritt(UTS: University of Technology, Sydney)H-Index: 52
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Abstract Objectives To determine the prevalence and characteristics of users of prayer or spiritual healing among Australian women aged 31–36 years. Design and setting This cross-sectional study was conducted as a part of the Australian Longitudinal Study on Women’s Health (ALSWH). The sample used in the current sub-study were participants from the ‘young’ cohort (1973–78) (n = 8180) aged between 31 and 36 years. Main outcome measure Use of prayer or spiritual healing Results Prayer or spiritual...
This article reviews coronary atheroma regression with statin therapy.Unlocking the mechanisms of atherogenesis and plaque progression has been fundamental to understanding the means by which contemporary antiatherosclerotic therapies lower cardiovascular risk. The advent of intracoronary imaging has helped chart the natural course of coronary atherosclerosis and evaluate therapeutic strategies that modify its natural progression. From earlier intravascular ultrasonography studies using lower do...
