Epiregulin can promote proliferation of stem cells from the dental apical papilla via MEK/Erk and JNK signalling pathways

Objectives Mesenchymal stem cells ( MSC s) are a reliable resource for tissue regeneration, but their molecular mechanisms of differentiation and proliferation remain unclear; this situation has restricted use of MSC s to a limited number of applications. A previous study of ours found a member of the epidermal growth factor family, epiregulin ( EREG ), to be involved in regulation of MSC differentiation. In the present study, we have used human...