Silver Succinylsulfadiazine and Silver Sulfadiazine Imidazole: Two New Derivatives of the Antibacterial Silver Sulfadiazine

Because of the low water solubility of silver sulfadiazine (0.34 mg/100 ml) the preparation of more soluble derivatives has been studied. One such derivative was prepared by the introduction of a succinyl group on the aromatic amino group of sulfadiazine. The silver compound had the composition Ag 2 (succinylsulfadiazine). The water solubility of this compound with respect to silver sulfadiazine was enhanced by the factor 2 for [sulfanilamide]...