Cytotoxicity to tumor cells of monocytes from normal individuals and cancer patients

This study was aimed at characterizing the parameters which regulate human monocyte‐mediated cytotoxicity to tumor cells as well as characterizing the target cell specificity, kinetics, etc., of the cytotoxic mechanism. Normal human peripheral blood monocytes were cytotoxic to tumor cells in an in vitro assay, measuring release of [ 3 H]thymidine from human target cells. Monocyte cytolysis was observed with several adherent tumor lines including...