Alan M. Kaplan
VCU Medical Center
CytotoxicityInternal medicineMitogen-activated protein kinaseEndocrinologyAntigenMolecular biologyCytotoxic T cellAntibodyInhibitory postsynaptic potentialRadioimmunoassayChemistryMononuclear phagocyte systemIn vitroImmunologyIn vivoHead and neck cancerChemotherapyPyranImmunotherapyLewis lung carcinomaAdjuvantMacrophageTrypan blueWound healingNeoplasmSpleenMonocytePyran CopolymerImmunopotentiatorLymphokineCancer researchDNAMedicineCell cultureBiologyGastroenterologyAntiserum
Publications 20
#1James P. Neifeld (MCV: VCU Medical Center)H-Index: 23
#2Jose J. Terz (City of Hope National Medical Center)H-Index: 31
Last. Walter Lawrence (MCV: VCU Medical Center)H-Index: 50
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Patients with primary squamous cell epitheliomas of the oral cavity, pharynx, and larynx were stratified according to stage and site and randomized to receive either intratumoral immunotherapy with Corynebacterium parvum followed 2 weeks later by surgery and postoperative C parvum for 2 years or surgery alone. There were 209 patients entered into the trial and 176 were fully evaluable. All prognostic variables were similar between the two groups. There was no difference in disease-free survival ...
6 CitationsSource
#1Winnie Chan (MCV: VCU Medical Center)H-Index: 14
#2S. Mcelhanon (MCV: VCU Medical Center)H-Index: 1
Last. William L. Banks (MCV: VCU Medical Center)H-Index: 7
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Abstract The effect of three feeding schedules on tumor and host were examined in Lewis Lung bearing (TB) and nontumor bearing (NTB) C57/B1 mice. Both NTB and TB animals were divided into three groups: the control groups which were fed ad libitum; the intermittent fed (IMF) groups were fed for 32 hr and fasted for 16 hr in each 48-hr cycle, and the alternate day fed (ADF) groups were fed for a 24-hr interval in each 48-hr cycle. The animals were killed at the end of the fifteenth day, following ...
1 CitationsSource
#1Robert F. Diegelmann (MCV: VCU Medical Center)H-Index: 63
#2Cohen Ik (MCV: VCU Medical Center)H-Index: 5
Last. Alan M. Kaplan (MCV: VCU Medical Center)H-Index: 12
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AbstractMouse peritoneal macrophages incubated with mouse 3T3 fibroblasts modulate DNA synthesis by the fibroblasts as measured by 125IUDR incorporation into DNA. The factor responsible for this activity is soluble and inhibits fibroblast DNA synthesis when present in high concentrations, whereas stimulation was observed at lower concentrations. Similar findings were observed when soluble fractions from human peripheral monocytes were incubated with primary human skin fibroblasts. In addition to...
19 CitationsSource
#1J.C. Waldrep (MCV: VCU Medical Center)H-Index: 4
#2T. Mohanakumar (MCV: VCU Medical Center)H-Index: 3
Last. Alan M. Kaplan (MCV: VCU Medical Center)H-Index: 12
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Abstract We have utilized the U937 macrophage cell line as a model system for analysis of human mononuclear phagocyte (MNP) differentiation. In addition to expressing membrane antigens shared with other MNP, U937 possesses an intrinsic ability to become “activated” upon exposure to lymphokines. A heteroantiserum produced against lymphokine-stimulated U937 (anti-U937L) was utilized to detect acquired or inducible membrane antigens expressed on “activated” U937. Absorption of this antiserum to rem...
13 CitationsSource
A golf putter having a sighting guide in the form of an elongated groove on the top of the club head and a plurality of channels on the bottom of the club head having a sloping angle from the face of the club angling downward toward the rear of the club so as to give an upward pressure to the club if it strikes the ground.
169 CitationsSource
#1J.C. Waldrep (MCV: VCU Medical Center)H-Index: 4
#2Alan M. Kaplan (MCV: VCU Medical Center)H-Index: 12
Last. T. Mohanakumar (MCV: VCU Medical Center)H-Index: 3
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Abstract Rabbit antisera were produced against a lymphokine-activated human macrophage cell line, U937 (αU937), and human peritoneal macrophages (αPEMO). After absorption with AB erythrocytes, pooled platelets, and B-lymphoblastoid cell lines, both antisera reacted by microcytotoxicity, indirect immunofluorescence (IF), and radioimmunoassay (RIA) with adherence-purified human peripheral blood monocytes, splenic and peritoneal macrophages, and leukemic myelomonoblasts. A panel of normal human T l...
10 CitationsSource
#1Theresa L. Gerrard (MCV: VCU Medical Center)H-Index: 2
#2Jose J. Terz (MCV: VCU Medical Center)H-Index: 10
Last. Alan M. Kaplan (MCV: VCU Medical Center)H-Index: 12
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This study was aimed at characterizing the parameters which regulate human monocyte-mediated cytotoxicity to tumor cells as well as characterizing the target cell specificity, kinetics, etc., of the cytotoxic mechanism. Normal human peripheral blood monocytes were cytotoxic to tumor cells in an in vitro assay, measuring release of [3H]thymidine from human target cells. Monocyte cytolysis was observed with several adherent tumor lines including T24, a bladder cancer line; LR, a melanoma line; and...
42 CitationsSource
#2Alan M. KaplanH-Index: 12
Last. Robert F. DiegelmannH-Index: 63
view all 4 authors...
#1Beatty Jd (MCV: VCU Medical Center)H-Index: 1
#2Terz JjH-Index: 1
Last. Alan M. KaplanH-Index: 12
view all 6 authors...
2 Citations
#1Harold F. Young (MCV: VCU Medical Center)H-Index: 49
#2Alan M. Kaplan (MCV: VCU Medical Center)H-Index: 12
Last. William Regelson (MCV: VCU Medical Center)H-Index: 22
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Autologous leukocytes (107 to 109), obtained with the Haemonetics's Leukaphoresis apparatus, were inoculated directly into recurrent glioblastoma tumors via indwelling catheters or by direct intratumoral injection through existing craniotomy openings. The rational use for autologous leukocyte (lymphocyte) infusions was based on in vitro autologous lymphocyte cytotoxicity to glioblastoma cells in the absence of serum inhibitory factors. Seven of 17 patients treated had life expectancy under 1 mon...
73 CitationsSource