Activation of human platelet-rich plasmas: effect on growth factors release, cell division and in vivo bone formation

Objectives: Aims of this controlled study were to determine the effects of activated human platelet‐rich plasmas (PRPs) on early and mature bone formation in vivo , and to characterize the effect of PRP activation on growth factors release and endothelial cell division in vitro . Material and methods: PRPs were prepared from four volunteers with the platelet concentrate collector system (PCCS) system and activated with three concentrations of...