Protein Sizing and Conformation Analysis with an Electro-Switchable DNA Chip

Powerful methods for analyzing proteins and their interactions with small molecules, nucleic acids or other proteins are a cornerstone in the development of new drugs and next-generation disease diagnostics. Commonly, affinity and kinetics of molecular interactions are determined with surface biosensors, which measure the adsorption/desorption of solute target molecules to/from surface immobilized capture molecules. However, information on...