Review paper
Identification and validation of vesicant therapeutic targets using a high-throughput siRNA screening approach
Abstract
Sulfur mustard [SM, bis-(2-chloroethyl) sulfide] is a highly reactive bifunctional alkylating agent that has been used as a vesicating agent in warfare scenarios to induce severe lung, skin, and eye injury. SM cutaneous lesions are characterized by both vesication and severe inflammation, but the molecular mechanisms that lead to these signs and symptoms are not well understood. There is a pressing need for effective therapeutics to treat this...
Paper Details
Title
Identification and validation of vesicant therapeutic targets using a high-throughput siRNA screening approach
Published Date
Dec 24, 2014
Journal
Volume
90
Issue
2
Pages
375 - 383
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Notes
History