Non-Smad signaling pathways
Abstract
Transforming growth factor-beta (TGFβ) is a key regulator of cell fate during embryogenesis and has also emerged as a potent driver of the epithelial-mesenchymal transition during tumor progression. TGFβ signals are transduced by transmembrane type I and type II serine/threonine kinase receptors (TβRI and TβRII, respectively). The activated TβR complex phosphorylates Smad2 and Smad3, converting them into transcriptional regulators that complex...
Paper Details
Title
Non-Smad signaling pathways
Published Date
Jun 24, 2011
Journal
Volume
347
Issue
1
Pages
11 - 20
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