Cell and Tissue Research
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#1Ke Hu (Bengbu Medical College)H-Index: 3
#2Chaofan He (Bengbu Medical College)H-Index: 3
Last. Meng Liang (Bengbu Medical College)H-Index: 3
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#1Corey R Fehlberg (UM: University of Miami)
#2Jae K Lee (UM: University of Miami)
Formation of a collagenous connective tissue scar null after penetrating injuries to the brain or spinal cord has been described and investigated for well over 100 years. However, it was studied almost exclusively in the context of penetrating injuries that resulted in infiltration of meningeal fibroblasts, which raised doubts about translational applicability to most CNS injuries where the meninges remain intact. Recent studies demonstrating the perivascular niche as a source of fibroblasts hav...
#1Lisa Rother (University of Würzburg)
#2Nadine Kraft (University of Würzburg)H-Index: 1
Last. Keram Pfeiffer (University of Würzburg)H-Index: 16
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In recent years, bumblebees have become a prominent insect model organism for a variety of biological disciplines, particularly to investigate learning behaviors as well as visual performance. Understanding these behaviors and their underlying neurobiological principles requires a clear understanding of brain anatomy. Furthermore, to be able to compare neuronal branching patterns across individuals, a common framework is required, which has led to the development of 3D standard brain atlases in ...
#1Shalaka Wahane (UCLA: University of California, Los Angeles)
#2Michael V. Sofroniew (UCLA: University of California, Los Angeles)H-Index: 79
Scar formation is the replacement of parenchymal cells by stromal cells and fibrotic extracellular matrix. Until as recently as 25 years ago, little was known about the major functional contributions of different neural and non-neural cell types in the formation of scar tissue and tissue fibrosis in the CNS. Concepts about CNS scar formation are evolving rapidly with the availability of different types of loss-of-function technologies that allow mechanistic probing of cellular and molecular func...
#1Tao Yang (CSU: Central South University)
#2Cuiyun Cai (CSU: Central South University)
Last. Qin Wang (CSU: Central South University)H-Index: 6
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Ischemia-reperfusion injury (I/R)-induced inflammatory process can mediate cochlea damage-related hearing loss; whether cochlear spiral ganglion progenitor cell-derived exosomes (CSGPC-exos) play a protective role by carrying functional microRNAs into recipient cells is unknown. Different doses of CSGPC-exos (0.1 μg/μl, 0.2 μg/μl, 0.5 μg/μl, 1.0 μg/μl) were administrated into the cochleae of the I/R group induced with 30-min occlusion of the bilateral vertebral arteries and sham surgery group. T...
#1Victoria N. Neckles (Clemson University)H-Index: 2
#2David M. Feliciano (Clemson University)H-Index: 14
Physiological functions require coordination of processes between diverse organs, tissues, and cells. This integrative view of science has reemerged complementary to the reductionist philosophy of studying individual cell types. An integrative approach has proven particularly powerful within the field of neuroscience where, intermingled among the most numerous neural cell types of the brain, are immune cells called microglia. Microglia act as a line of defense in the CNS by phagocytizing harmful...
#1Nicola Wanner (UHH: University of Hamburg)H-Index: 16
#2Thomas Eden (UHH: University of Hamburg)H-Index: 3
Last. Friedrich Koch-Nolte (UHH: University of Hamburg)H-Index: 62
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Current therapeutic options for renal diseases are limited, and the search for disease-specific treatments is ongoing. Nanobodies, single-domain antibodies with many advantages over conventional antibodies, provide flexible, easy-to-format biologicals with many possible applications. Here, we discuss the potential use of nanobodies for renal diseases.
#1Yu Zhao (UHH: University of Hamburg)H-Index: 2
#2Ulf Panzer (UHH: University of Hamburg)H-Index: 59
Last. Christian Krebs (UHH: University of Hamburg)H-Index: 25
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Single-cell biology is transforming the ability of researchers to understand cellular signaling and identity across medical and biological disciplines. Especially for immune-mediated diseases, a single-cell look at immune cell subtypes, signaling, and activity might yield fundamental insights into the disease etiology, mechanisms, and potential therapeutic interventions. In this review, we highlight recent advances in the field of single-cell RNA profiling and their application to understand ren...
#1Amanda Phuong Tran (Seattle Children's Research Institute)H-Index: 11
#2Philippa Mary Warren (Wolfson Centre for Age-Related Diseases)H-Index: 3
Last. Jerry Silver (Case Western Reserve University)H-Index: 85
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Severe spinal cord injury causes permanent loss of function and sensation throughout the body. The trauma causes a multifaceted torrent of pathophysiological processes which ultimately act to form a complex structure, permanently remodeling the cellular architecture and extracellular matrix. This structure is traditionally termed the glial/fibrotic scar. Similar cellular formations occur following stroke, infection, and neurodegenerative diseases of the central nervous system (CNS) signifying th...
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#1Navid Koleini (UM: University of Manitoba)H-Index: 8
#2Barbara E. NickelH-Index: 19
Last. Elissavet KardamiH-Index: 44
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Fibroblast growth factor 2 (FGF2), produced as high (Hi-) and low (Lo-) molecular weight isoforms, is implicated in cardiac response to injury. The role of endogenous FGF2 isoforms during chronic stress is not well defined. We investigated the effects of endogenous Hi-FGF2 in a mouse model of simulated pressure-overload stress achieved by transverse aortic constriction (TAC) surgery. Hi-FGF2 knockout mice, expressing only Lo-FGF2, FGF2(Lo), and wild-type mice, FGF2(WT), expressing both Hi-FGF2 a...
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Molecular biology
Cell biology