Acid‐sensing ion channel 1: A novel therapeutic target for migraine with aura

Objective: Migraine with aura is a severe debilitating neurological disorder with few relatively specific therapeutic options. Methods: We used amiloride, a blocker of epithelial sodium channels, to evaluate its pharmacological potential and explored the biology of a potential mechanism of action in well‐established experimental models. Results: Amiloride was shown to block cortical spreading depression, the experimental correlate of aura, and...