Review paper
Regulating the p53 pathway: in vitro hypotheses, in vivo veritas
Abstract
Mutations in TP53, the gene that encodes the tumour suppressor p53, are found in 50% of human cancers, and increased levels of its negative regulators MDM2 and MDM4 (also known as MDMX) downregulate p53 function in many of the rest. Understanding p53 regulation remains a crucial goal to design broadly applicable anticancer strategies based on this pathway. This Review of in vitro studies, human tumour data and recent mouse models shows that p53...
Paper Details
Title
Regulating the p53 pathway: in vitro hypotheses, in vivo veritas
Published Date
Dec 1, 2006
Journal
Volume
6
Issue
12
Pages
909 - 923
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