Brain region and sex differences in age association with brain volume: a quantitative MRI study of healthy young adults.

Published on Jan 1, 2002in American Journal of Geriatric Psychiatry3.393
· DOI :10.1097/00019442-200201000-00009
Ruben C. Gur148
Estimated H-index: 148
(UPenn: University of Pennsylvania),
Faith M. Gunning-Dixon30
Estimated H-index: 30
(UPenn: University of Pennsylvania)
+ 2 AuthorsRaquel E. Gur142
Estimated H-index: 142
(UPenn: University of Pennsylvania)
There is evidence that some brain regions show age-associated volume decline and that men undergo more accelerated cerebral aging than women. However, limited information is available on age-associated changes during young adulthood. The authors performed quantitative magnetic resonance imaging in 116 healthy young adults (57 men, 59 women; age range: 18–49 years) to evaluate the relationship of age and sex with volumes of frontal and temporal regions, including selected limbic structures and the basal ganglia. Regardless of sex, increasing age was moderately associated with decrease in total gray matter (GM) and mildly with increase in sulcal cerebrospinal fluid (CSF). Associations of age with reduced GM volume were observed in all frontal and temporal cortical regions and some basal ganglia structures, but were generally less prominent in subcortical regions. The associations were stronger for men than women in the dorsolateral prefrontal cortex. Thus, in young, healthy adults, age-associated changes are selective as well as sex-specific, with men experiencing greater volume decrement across age-groups than women, particularly in the dorsolateral prefrontal regions. Reduced GM and increased CSF in this age range suggests that the aging process is a continuum, with changes evident before senescence. Thus, the biological changes commonly attributed to "aging" do, in fact, begin much earlier in the life-cycle.
📖 Papers frequently viewed together
3,920 Citations
360 Citations
470 Citations
#1David A. DrachmanH-Index: 1
#1Martin L. AlbertH-Index: 53
Last. Janice E. KnoefelH-Index: 10
view all 2 authors...
Clinica;l Neurology of Aging is a comprehensive text and reference work that covers the scientific foundations and also offers much practical clinical advice on the diagnosis and management of neurological disorders in the aged. The book is divided into six sections: Scientific Basis of Geriatric Neurology, Clinical Examination and Diagnostic Studies, Mental Status, Special Senses, Motor Control and Peripheral Nerve Function, and Common Neurologic Conditions in the Elderly. This thorough revisio...
345 Citations
#1George PaxinosH-Index: 79
#2Jürgen K. MaiH-Index: 26
Section I: Evolution and Development Section II: Peripheral Nervous System and Spinal Cord Section III: Brainstem and Cerebellum Section IV: Diencephalon, Basal Ganglia and Amygdala Section V: Cortex Section IV: Systems
1,480 Citations
#1Junko MatsuzawaH-Index: 2
#2Mie MatsuiH-Index: 32
Last. Toshio MiyawakiH-Index: 58
view all 7 authors...
To date there is little information about brain development during infancy and childhood, although several quantitative studies have shown volume changes in adult brains. We performed threedimensional magnetic resonance imaging (3D-MRI) in 28 healthy children aged 1 month to 10 years. We examined the volumes of whole brain and frontal and temporal lobes with an advanced method for segmenting images into gray matter (GM), white matter (WM) and cerebrospinal fluid (CSF) compartments. Growth spurts...
238 CitationsSource
#1Luis M. Garcia-Segura (CSIC: Spanish National Research Council)H-Index: 102
#2Iñigo Azcoitia (Complutense University of Madrid)H-Index: 59
Last. Lydia L. DonCarlos (LUC: Loyola University Chicago)H-Index: 30
view all 3 authors...
This review highlights recent evidence from clinical and basic science studies supporting a role for estrogen in neuroprotection. Accumulated clinical evidence suggests that estrogen exposure decreases the risk and delays the onset and progression of Alzheimer’s disease and schizophrenia, and may also enhance recovery from traumatic neurological injury such as stroke. Recent basic science studies show that not only does exogenous estradiol decrease the response to various forms of insult, but th...
844 CitationsSource
#1Raquel E. Gur (UPenn: University of Pennsylvania)H-Index: 142
#2Bruce I. TuretskyH-Index: 64
Last. Ruben C. GurH-Index: 148
view all 9 authors...
Background Neuroanatomic studies of schizophrenia have reported temporolimbic abnormalities. Most magnetic resonance imaging studies have evaluated small samples of primarily men with chronic schizophrenia. Our goal was to evaluate sex differences in segmented temporal lobe subregions with reliable parcellation methods, relating volume with clinical and neurocognitive parameters. Methods Magnetic resonance imaging was performed in 100 patients with schizophrenia (58 men, 42 women; 39 neuroleptic...
320 CitationsSource
#1Raquel E. Gur (UPenn: University of Pennsylvania)H-Index: 142
#2Patricia E. CowellH-Index: 27
Last. Ruben C. GurH-Index: 148
view all 8 authors...
Background Converging neuroanatomic, neurophysiological, and neurobehavioral evidence implicate prefrontal subregions in schizophrenia. Neuroanatomic studies with magnetic resonance (MR) imaging enable regional volume parcellation. Inconsistent reports may relate to variable methods and small samples. We attempted to resolve volume differences within sectors of the prefrontal lobe in a large sample, relating volumes to clinical and neurocognitive features. Methods Magnetic resonance imaging was ...
336 CitationsSource
#1Susan M. ResnickH-Index: 38
Last. Alan B. ZondermanH-Index: 107
view all 8 authors...
Longitudinal studies indicate that declines in cognition and memory accelerate after age 70 years. The neuroanatomic and neurophysiologic underpinnings of cognitive change are unclear, as there is little information on longitudinal brain changes. We are conducting a longitudinal neuroimaging study of nondemented older participants in the Baltimore Longitudinal Study of Aging. This report focuses on age and sex differences in brain structure measured by magnetic resonance imaging during the first...
443 CitationsSource
#1Naftali RazH-Index: 78
846 Citations
#1Jiang XuH-Index: 3
#2Shotai KobayashiH-Index: 59
Last. Kazuya YamashitaH-Index: 12
view all 6 authors...
BACKGROUND AND PURPOSE: Previous reports have suggested that brain atrophy is associated with aging and that there are gender differences in brain atrophy with aging. These reports, however, neither exclude silent brain lesions in “healthy subjects” nor divide the brain into subregions. The aim of this study is to clarify the effect of gender on age-related changes in brain subregions by MR imaging. METHODS: A computer-assisted system was used to calculate the brain matter area index (BMAI) of v...
204 Citations
#1Tomáš Paus (Montreal Neurological Institute and Hospital)H-Index: 108
#2Alex P. ZijdenbosH-Index: 43
Last. Alan C. EvansH-Index: 65
view all 8 authors...
Structural maturation of fiber tracts in the human brain, including an increase in the diameter and myelination of axons, may play a role in cognitive development during childhood and adolescence. A computational analysis of structural magnetic resonance images obtained in 111 children and adolescents revealed age-related increases in white matter density in fiber tracts constituting putative corticospinal and frontotemporal pathways. The maturation of the corticospinal tract was bilateral, wher...
1,134 CitationsSource
Cited By93
#1Simon M. Hofmann (MPG: Max Planck Society)H-Index: 2
#2Frauke Beyer (MPG: Max Planck Society)H-Index: 12
Last. A. V. Witte (MPG: Max Planck Society)H-Index: 4
view all 8 authors...
Brain-age (BA) estimates based on deep learning are increasingly used as neuroimaging biomarker for brain health; however, the underlying neural features have remained unclear. We combined ensembles of convolutional neural networks with Layer-wise Relevance Propagation (LRP) to detect which brain features contribute to BA. Trained on magnetic resonance imaging (MRI) data of a population-based study (n=2637, 18-82 years), our models estimated age accurately based on single and multiple modalities...
#1Hannah McCann (Cardiff University)H-Index: 3
#2Leandro Beltrachini (Cardiff University)H-Index: 12
OBJECTIVE Understanding the induced current flow from transcranial direct current stimulation (tDCS) is essential for determining the optimal dose and treatment. Head tissue conductivities play a key role in the resulting electromagnetic fields. However, there exists a complicated relationship between skull conductivity and participant age, that remains unclear. We explored how variations in skull electrical conductivities, particularly as a suggested function of age, affected tDCS induced elect...
#1Andrei Irimia (SC: University of Southern California)H-Index: 25
Accurate knowledge of adult human brain volume (BV) is critical for studies of aging- and disease-related brain alterations, and for monitoring the trajectories of neural and cognitive functions in conditions like Alzheimer’s disease and traumatic brain injury. This scoping meta-analysis aggregates normative reference values for BV and three related volumetrics—gray matter volume (GMV), white matter volume (WMV) and cerebrospinal fluid volume (CSFV)—from typically-aging adults studied cross-sect...
1 CitationsSource
#1Xin Zeng (Tongji University)H-Index: 2
#1Xin Zeng ('SMMU': Second Military Medical University)H-Index: 39
Last. Wei-Fen Xie ('SMMU': Second Military Medical University)H-Index: 32
view all 17 authors...
Abstract Background & Aims The EncephalApp Stroop test is a high-sensitivity but low-specificity test that has been used to identify patients with covert hepatic encephalopathy (CHE). We aimed to develop a new strategy to detect CHE, combining EncephalApp Stroop test score with scores from subtests of the psychometric hepatic encephalopathy scoring system (PHES). Methods We performed a survey of 569 adult volunteers (229 men) in 9 communities in Shanghai, China, administering the EncephalApp Str...
2 CitationsSource
#1Andrei Irimia (SC: University of Southern California)H-Index: 25
Accurate knowledge of adult human brain volume (BV) is critical for studies of aging- and disease-related brain alterations, and for monitoring the trajectories of neural and cognitive functions in conditions like Alzheimer9s disease and traumatic brain injury. This scoping meta-analysis aggregates normative reference values for BV and three related volumetrics -- volume (GMV), white matter volume (WMV) and cerebrospinal fluid volume (CSFV) -- from typically-aging adults studied cross-sectionall...
#1Julie Walsh-Messinger (Wright State University)H-Index: 10
#2Christine Stepanek (ISMMS: Icahn School of Medicine at Mount Sinai)
Last. Dolores Malaspina (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 80
view all 6 authors...
ABSTRACTThe ability to mentalize, or theory of mind (ToM), is sexually dimorphic in humans and impaired in schizophrenia. This sex-stratified study probed cognitive (indexed by intelligence) and af...
#1Hirokazu Kumazaki (Kanazawa University)H-Index: 11
#2Taro Muramatsu (Keio: Keio University)H-Index: 42
Last. Mitsuru Kikuchi (Kanazawa University)H-Index: 34
view all 6 authors...
Olfactory adaptation is an important process that allows the individual to adjust to changes in the environment. This process has been proposed to be aberrant in individuals with autism spectrum disorders (ASD). However, few studies have examined olfactory adaptation in children with ASD. We examined olfactory adaptation in children with ASD and typically developing (TD) children using a pulse ejection system, which resolved problems associated with previous laboratory-based olfactory psychophys...
3 CitationsSource
#1Pareek (National Brain Research Centre)H-Index: 1
#1Vikas Pareek (National Brain Research Centre)H-Index: 8
Last. Prasun K. Roy (IIT: Indian Institute of Technology (BHU) Varanasi)H-Index: 2
view all 3 authors...
We investigate the relationship between Gray matter’s volume vis-a-vis White matter’s integrity indices, such Axial diffusivity, Radial diffusivity, Mean diffusivity, and Fractional anisotropy, in ...
6 CitationsSource
#1Kazuko Hotta (Tokai University)H-Index: 3
#2Takatoshi Sorimachi (Tokai University)H-Index: 15
Last. Mitsunori Matsumae (Tokai University)H-Index: 22
view all 4 authors...
Objective Sex differences in various diseases recently have been recognized as an important factor in the approach to more efficient preventive and therapeutic medicine. We clarified sex differences in the clinical characteristics of chronic subdural hematoma (CSDH) by comparing men and women with CSDH, as there is a well-known male predominance in the prevalence of CSDH. Methods Clinical factors and computed tomography findings were investigated retrospectively in 490 consecutive patients admit...
2 CitationsSource
#1Vindhya Ekanayake (NIH: National Institutes of Health)H-Index: 8
#2Sarah M. Kranick (NIH: National Institutes of Health)H-Index: 17
Last. Valerie Voon (University of Cambridge)H-Index: 73
view all 8 authors...
Abstract Objective Psychogenic movement disorder (PMD) and psychogenic nonepileptic seizures (PNES) are two subtypes of conversion disorder (CD). In this case-control study, we asked whether these subtypes varied as a function of personality and history of childhood abuse. Methods Fifty-nine patients with PMD from the Human Motor Control Section Clinic at the National Institutes of Health, 43 patients with PNES from the Rhode Island Hospital Neuropsychiatry and Behavioral Neurology Division, and...
34 CitationsSource