The non–major histocompatibility complex quantitative trait locus Cia10 contains a major arthritis gene and regulates disease severity, pannus formation, and joint damage

Objective To construct rats congenic for the chromosome 2 arthritis‐regulatory quantitative trait locus Cia10 , originally identified in a (DA × ACI)F 2 intercross rat strain that had been assessed for collagen‐induced arthritis (CIA), and to determine the effect of this congenic interval on arthritis severity, joint histologic structure, and cytokine transcription in rats with pristane‐induced arthritis (PIA). Methods A 52.6‐MB interval derived...