Arthritis & Rheumatism
IF
9.59
Papers
22.7k
Papers 10,000
1 page of 1,000 pages (10k results)
#1Justin Bucci (BU: Boston University)
#2X. Chen (BU: Boston University)H-Index: 2
Last. David T. Felson (University of Manchester)H-Index: 128
view all 7 authors...
Objective null To determine whether intra-articular corticosteroid injections are associated with increased knee osteoarthritis progression compared to hyaluronic acid injections which has been reported to delay OA progression and knee replacement. null Methods null We identified participants from two large cohort studies, the Osteoarthritis Initiative and the Multicenter Osteoarthritis Study. Study visits were performed at regular intervals and included questionnaires about intraarticular corti...
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#1Joshua C Cheng (SBU: Stony Brook University)
#2Alessandra Anzolin (Harvard University)H-Index: 5
Last. Vitaly Napadow (Harvard University)H-Index: 54
view all 13 authors...
Objective null Abnormal central pain processing is a leading etiology underlying fibromyalgia (FM) pain and is perceptually characterized with the psychophysical measure of temporal summation of pain (TSP). TSP is the perception of increasingly greater pain to repetitive or tonic noxious stimuli. Previous neuroimaging studies have used static (i.e. summary) measures to examine the fMRI correlates of TSP in FM. However, functional brain activity rapidly and dynamically reorganizes across time, an...
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#1Iain B. McInnes (University of Glasgow)H-Index: 97
#2Proton Rahman (MUN: Memorial University of Newfoundland)H-Index: 45
Last. Philip J. Mease (UW: University of Washington)H-Index: 79
view all 12 authors...
OBJECTIVE Assess long-term efficacy and safety of guselkumab, an IL-23p19-subunit inhibitor, in patients with active psoriatic arthritis (PsA) from the Phase-3 DISCOVER-2 trial. METHODS In DISCOVER-2, patients with active PsA (≥5 swollen and ≥5 tender joints; CRP ≥0.6 mg/dL) despite prior nonbiologic therapy were randomized to: guselkumab 100mg every-4-weeks (Q4W); at Week0, Week4, and Q8W; or placebo➔guselkumab Q4W at Week24. Efficacy assessments included ≥20%/50%/70% improvement in ACR compone...
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#1Jian Liu (ZMU: Zunyi Medical University)
#2Xinge Cheng (ZMU: Zunyi Medical University)H-Index: 2
Last. Xianchun ZengH-Index: 2
view all 4 authors...
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#1Peter R W Gowler (University of Nottingham)H-Index: 5
#2James Turnbull (University of Nottingham)H-Index: 2
Last. Victoria Chapman (University of Nottingham)H-Index: 54
view all 16 authors...
Objective Chronic pain due to osteoarthritis (OA) is a major clinical problem, existing analgesics often have limited beneficial effects and/or adverse effects, necessitating the development of novel therapies. Epoxyeicosatrienoic acids (EETs) are endogenous anti-inflammatory mediators, rapidly metabolized by soluble epoxide hydrolase (sEH) to dihydroxyeicosatrienoic acids (DHETs). We hypothesized that sEH driven metabolism of the EETs to DHETs plays a critical role in chronic joint pain associa...
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#1Francesco MuratoreH-Index: 15
#2Chiara MarvisiH-Index: 5
Last. Carlo SalvaraniH-Index: 51
view all 15 authors...
Objectives null We used a clinically oriented phenotype-first approach to identify patients with VEXAS syndrome from a single-center cohort of Italian patients with vasculitis. null Methods null The clinical records of 147 consecutive male patients followed in our vasculitis clinic from 2013 to date were retrospectively reviewed. All patients with a diagnosis of vasculitis and inflammatory manifestations resistant to treatment, persistently elevated inflammatory markers, and hematologic abnormal...
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#1Yukiko Kimura (Boston Children's Hospital)H-Index: 7
#2Laura E. Schanberg (Duke University)H-Index: 36
Last. Brian M. Feldman (Hospital for Sick Children)H-Index: 61
view all 12 authors...
OBJECTIVE The optimal time to start biologics in polyarticular juvenile idiopathic arthritis (JIA) remains uncertain. The Childhood Arthritis and Rheumatology Research Alliance (CARRA) developed 3 consensus treatment plans (CTPs) for untreated polyarticular JIA to compare strategies for starting biologics. METHODS Start Time Optimization of Biologics in Polyarticular JIA (STOP-JIA) was a prospective, observational, CARRA Registry study comparing the effectiveness of 3 CTPs: 1) the step-up plan (...
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#1Chiara Trincianti (UniGe: University of Genoa)H-Index: 2
#2Evert Hendrik Pieter van Dijkhuizen (Istituto Giannina Gaslini)H-Index: 3
Last. Pierre Quartier (Hôpital Necker-Enfants Malades)H-Index: 49
view all 21 authors...
OBJECTIVE To develop and validate new Juvenile Arthritis Disease Activity Score 10 (JADAS10) and clinical JADAS10 (cJADAS10) cutoffs to separate the states of inactive disease (ID), minimal disease activity (MiDA), moderate disease activity (MoDA), and high disease activity (HDA) in children with oligoarthritis and with rheumatoid factor-negative polyarthritis, based on subjective disease assessment by the treating pediatric rheumatologist. METHODS The cutoffs definition cohort was composed of 1...
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#1Qianqian Liu (NU: Nanjing University)H-Index: 1
#2Linhui Zhai (CAS: Chinese Academy of Sciences)H-Index: 8
Last. Yang Sun (NU: Nanjing University)H-Index: 44
view all 15 authors...
Objective null Protein tyrosine kinases (PTKs) regulate osteoarthritis (OA) progression by activating a series of signal transduction pathways. However, the roles of protein tyrosine phosphatases (PTPs) in OA remain obscure. null Methods null The expression of 107 PTP genes in human OA cartilage was analyzed based on a single-cell sequencing dataset. The enzyme activity of the PTP SHP2 was detected in primary chondrocytes after interleukin (IL)-1β treatment and in human OA cartilage. Destabilize...
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#1Cindy Orvain (INSERM: Inserm)H-Index: 2
#2Morgane Boulch (Délégation Paris 7)H-Index: 1
Last. Jérôme Avouac (Délégation Paris 5)H-Index: 50
view all 5 authors...
Chimeric antigen receptor-T (CAR-T) cell therapy is based on specific targeting of tumor antigens, leading to lysis and destruction of tumor cells. The high potency of CAR-T cells in the management of B cell malignancies has been demonstrated. Following the success of this therapeutic strategy, new CAR-T cell-derived constructs that have the ability to eradicate pathogenic B cells or restore tolerance have been developed. The present review discusses how the knowledge and technology generated by...
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