Hemostatic Factors and Replacement of Major Blood Loss with Plasma-Poor Red Cell Concentrates

The purpose of this study was to assess the change of platelet and fibrinogen concentrations and the change of activities of prothrombin and factors V and VII when major surgical blood loss was replaced with plasmapoor red cell concentrates (RCCs) and colloid plasma substitutes.Sixty patients were studied. The average blood loss was 65% +/- 41% of the calculated blood volume (CBV). Blood loss was monitored carefully and replaced without delay to...