Review paper
Pheochromocytoma and paraganglioma pathogenesis: learning from genetic heterogeneity
Abstract
The neuroendocrine tumours pheochromocytomas and paragangliomas carry the highest degree of heritability in human neoplasms, enabling genetic alterations to be traced to clinical phenotypes through their transmission in families. Mutations in more than a dozen distinct susceptibility genes have implicated multiple pathways in these tumours, offering insights into kinase downstream signalling interactions and hypoxia regulation, and uncovering...
Paper Details
Title
Pheochromocytoma and paraganglioma pathogenesis: learning from genetic heterogeneity
Published Date
Jan 20, 2014
Journal
Volume
14
Issue
2
Pages
108 - 119
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