Cyclooxygenase-2 Regulates Th17 Cell Differentiation during Allergic Lung Inflammation

Rationale: Th17 cells comprise a distinct lineage of proinflammatory T helper cells that are major contributors to allergic responses. It is unknown whether cyclooxygenase (COX)-derived eicosanoids regulate Th17 cells during allergic lung inflammation.Objectives: To determine the role of COX metabolites in regulating Th17 cell differentiation and function during allergic lung inflammation.Methods: COX-1−/−, COX-2−/−, and wild-type mice were...