Fabrication of nano-fibrous poly(l-lactic acid) scaffold reinforced by surface modified chitosan micro-fiber

To mimic the fibrillar structure of natural extracellular matrix and optimize the chemical composition of the scaffold, a nano-fibrous poly(l-lactic acid) (PLLA) scaffold reinforced by surface modified chitosan micro-fiber (MCTSF) was fabricated using the thermally induced phase separation method. The composite scaffold has a novel structure comprised of a nano-matrix with reinforcing micro-fibers, in which the nano-fibrous PLLA matrix promotes...