Infiltration of dendritic cells and T lymphocytes predicts favorable outcome in epithelial ovarian cancer.

Published on Feb 27, 2015in Cancer Gene Therapy5.987
路 DOI :10.1038/CGT.2015.7
Zhengmao Zhang6
Estimated H-index: 6
(Hebei Medical University),
Jian Huang109
Estimated H-index: 109
(SJTU: Shanghai Jiao Tong University)
+ 10 AuthorsBaoen Shan5
Estimated H-index: 5
Sources
Abstract
Infiltration of dendritic cells and T lymphocytes predicts favorable outcome in epithelial ovarian cancer
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19991.37Hno
4 Authors (P. Jecker, ..., Martin Westhofen)
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#1Ninke Leffers (UMCG: University Medical Center Groningen)H-Index: 19
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Purpose Ovarian cancer patients with intra-tumoral CD3+ T-lymphocytes in primary tumor tissue have a better prognosis. This study aims to analyze the presence and relative influence of three important T-lymphocyte subsets, tumor-infiltrating CD8+ cytotoxic T-lymphocytes (CTL), CD45R0+ memory T-lymphocytes, and FoxP3+ regulatory T-lymphocytes (Treg), in primary tumor tissue and omental metastases of patients with ovarian cancer.
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Introduction Although systemic T-cell responses against tumor antigens and tumor infiltration by T cells have been investigated in colorectal cancer (CRC), the initiation of spontaneous immune responses in situ is not well understood. Macrophages and dendritic cells (DC) play an important role as a link between innate and adaptive immune response. The aim of the present study was to analyze macrophage and DC infiltration in CRC and to investigate whether there is a correlation to systemic T-cell...
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Cervical carcinoma is the second leading cancer in women in Malaysia, after breast cancer. Human papillomavirus (HPV) has been implicated in the development of dysplasia or cervical intraepithelial neoplasia and progression to squamous cell carcinoma. Because of the confinement of the human papillomavirus infection within the epithelial layer, the presence of dentritic cells or Langerhans cells in epithelial layer of the ectocervix is paramount in producing immune response. The mature dentritic ...
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CD1鍒嗗瓙鐨勬姉鍘熸彁鍛堟槸鐙珛浜嶮HC鈪犲拰MHC鈪′互澶栫殑閫斿緞,瀹冨湪鎶楀師鐨勮杞姐佽優鍐呰繍杈撳強鍏跺姞宸ュ鐞嗙瓑鏂归潰閮界嫭鍏风壒鑹.涓嶅悓鐨勭墿绉嶅彲鑳芥湁涔熷彲鑳芥病鏈塁D1鍩哄洜,浣撳唴瀛樺湪CD1鍩哄洜鐨勭敓鐗╂墍鍖呭惈鐨凜D1铔嬬櫧鍦ㄦ暟閲忓拰绉嶇被涓婁篃涓嶅敖鐩稿悓.CD1铔嬬櫧涓嶮HC鍒嗗瓙鐨勭粨鏋勯潪甯哥浉浼,鐒惰屼簩鑰呰瘑鍒粨鍚堢殑鎶楀師鐗╄川鍗村湪鐢熷寲鎬ц川鍙婄墿鐞嗙粨鏋勪笂鏈夋湰璐ㄧ殑鍖哄埆.涓嶄粎CD1鍒嗗瓙涓嶮HC鍒嗗瓙鎶楀師璇嗗埆鏈哄埗涓嶅悓,鑰屼笖CD1瀹舵棌鍐呴儴鍚勫垎瀛愪箣闂村湪璇嗗埆鑴傜被鎶楀師鏃朵篃鏈夊尯鍒.CD1鍒嗗瓙鐨勭粍瑁呭拰鑳炲唴杩愯緭璺嚎鍜孧HC鍒嗗瓙鐨勬槑鏄句笉鍚屻
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Aim: To elucidate the relationship between local immunocompetent cells and prognosis of human hepatocellular carcinoma (HCC) after resection. Methods: HE staining and immunohistochemical study were carried out on specimens from patients underwent surgical resection. Local immunocompetent cells, such as dendritic cells (DCs), memory T cells, CD3+ T lymphocytes and CD8+ T lymphocytes, were counted and their relationships with tumor-free survival rate were analyzed by grouping DCs with the T lympho...
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BACKGROUND OBJECTIVE: Dendritic cells (DCs) are the most important antigen-presenting cells. CD1a, a marker of immature DCs, plays a role in tumorigenesis. This study was designed to explore the correlation of CD1a+ DCs to pathologic degree, T stage, local recurrence, and prognosis of glottic squamous cell carcinoma. METHODS: Clinical and follow-up data of 111 patients with glottic squamous cell carcinoma were analyzed retrospectively. The expression of CD1a+ DCs in the 111 specimens of glottic ...
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Mature dendritic cells (DCs) play an important role as antigen-presenting cells in tumor immunity. The angiogenic factor, vascular endothelial growth factor (VEGF), inhibits DC maturation. In this study, 174 gastric cancer patients were assessed by immunohistochemistry using anti-S-100 antibody for total DCs, anti-CD83 antibody for mature DCs and anti-VEGF antibody for VEGF expression, and the relationships between total DC density (TDD), mature DC density (MDD), clinicopathological factors, VEG...
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Objective:To evaluate the predictive role of S-100 positive dendritic cell, tissue inhibitor of metalloproteinases-1 (TIMP-1) and p63 gene in primary laryngeal carcinoma with epidemiology(smoking and drinking), histological grading, surgical treatment,TNM stage and prognosis by the tissuechip technology. Method:We studied the expression of dendritic cell(S-100), TIMP-1 and p63 gene on a series of 85 primary laryngeal carcinoma patients who had ever received in our hospital between 1992 and 2000 ...
#1Gang XiaoH-Index: 2
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Objective To investigate the alternation and significance of CD4 +CD45RA + T cells and CD4 +CD45RO + T cells in peripheral blood of colorectal cancer patients. Methods The expression of CD4 + T cells, CD4 +CD45RA + T cells and CD4 +CD45RO + T cells in peripheral blood of 60 colorectal cancer patients were detected with flow cytometry pre operatively and 1, 3 months post operatively, compared with those of 10 healthy persons. Results CD4 + T cells expression of colorectal cancer patients was the ...
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// Alia Ghoneum 1 , Hesham Afify 1 , Ziyan Salih 2 , Michael Kelly 3 and Neveen Said 1, 2, 4 1 Department of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA 2 Department of Cancer Pathology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA 3 Department of Cancer Obstetrics and Gynecology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA 4 Department of Cancer Urology, Wake Forest University School of Medicine, ...
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