Cancer Gene Therapy
Papers 2,429
1 page of 243 pages (2,429 results)
#1Hongjin Chen (NMU: Nanjing Medical University)H-Index: 3
#2Fubing Wu (NMU: Nanjing Medical University)H-Index: 1
Last. Hongping Xia (NMU: Nanjing Medical University)H-Index: 12
view all 10 authors...
Hepatocellular carcinoma (HCC) is one of the deadliest cancer types worldwide. The centromere proteins (CENPs) are critical for the mitosis-related protein complex and are involved in kinetochore assembly and spindle checkpoint signaling during mitosis. However, the clinical significance of CENPs in the recurrence and progression of HCC remains poorly understood. Here, we examined the expression of all CENPs and their association with recurrence and survival of HCC patients using the global gene...
#1Shufeng XuH-Index: 4
#2Lei ZhengH-Index: 4
Last. Li-Ming GaoH-Index: 5
view all 5 authors...
Non-small-cell lung cancer (NSCLC) remains the leading cause of cancer-related death worldwide. Accumulating research has highlighted the ability of exosome-encapsulated microRNAs (miRNAs or miRs) as potential circulating biomarkers for lung cancer. The current study aimed to evaluate the clinical significance of serum-derived exosomal miR-let-7e as a biomarker in the metastasis of NSCLC. Initially, the expression of miR-let-7e, SUV39H2, and CDH1 in human NSCLC tissues and exosomes isolated from...
#1Dean C. Singleton (University of Auckland)H-Index: 11
#2Alexandra M. Mowday (University of Auckland)H-Index: 9
Last. Adam V. Patterson (University of Auckland)H-Index: 36
view all 10 authors...
Advances in the field of cancer immunotherapy have stimulated renewed interest in adenoviruses as oncolytic agents. Clinical experience has shown that oncolytic adenoviruses are safe and well tolerated but possess modest single-agent activity. One approach to improve the potency of oncolytic viruses is to utilise their tumour selectivity to deliver genes encoding prodrug-activating enzymes. These enzymes can convert prodrugs into cytotoxic species within the tumour; however, these cytotoxins can...
#1Viviana Vella (University of Sussex)H-Index: 3
#2Georgios Giamas (University of Sussex)H-Index: 25
Last. Angeliki Ditsiou (University of Sussex)H-Index: 4
view all 3 authors...
#1Rachel A Montel (CU: Cornell University)
#2Carlos Munoz-Zuluaga (CU: Cornell University)
Last. Ronald G. Crystal (CU: Cornell University)H-Index: 125
view all 4 authors...
Approximately 8% of the world population and 35-45% of East Asians are carriers of the hereditary disorder aldehyde dehydrogenase 2 (ALDH2) deficiency. ALDH2 plays a central role in the liver to metabolize ethanol. With the common E487K variant, there is a deficiency of ALDH2 function; when ethanol is consumed, there is a systemic accumulation of acetaldehyde, an intermediate product in ethanol metabolism. In ALDH2-deficient individuals, ethanol consumption acutely causes the "Alcohol Flushing S...
#1Dong Zhang (XJTU: Xi'an Jiaotong University)H-Index: 4
#2Xiaojie Yang (XJTU: Xi'an Jiaotong University)H-Index: 4
Last. Tie Chong (XJTU: Xi'an Jiaotong University)H-Index: 11
view all 5 authors...
Prostate cancer (PCa) is a commonly diagnosed malignancy in men. The transcription factor p53, a well-known cancer suppressor, has been extensively analyzed in the progression of many tumor types, but its involvement in PCa remains not fully understood. Hence, this study aims to explore the possible molecular mechanism underlying p53 in the growth and metastasis of PCa. Based on bioinformatics analysis findings of GEPIA and starBase databases, p53 was demonstrated to be involved in the developme...
#1Huadong Chen (Sun Yat-sen University)H-Index: 5
#2Fuxi Li (Sun Yat-sen University)H-Index: 6
Last. Wen-Zong Gao (Sun Yat-sen University)
view all 6 authors...
N6-methyladenosine (m6A) RNA methylation and its associated methyltransferase METTL3 play an important role in tumorigenesis of a series of tumors. However, dysregulation of METTL3 in gallbladder cancer (GBC) remains obscure. Here, we showed that upregulated METTL3 level predicted poor prognosis and correlated with increased lymphatic metastasis and high TNM stage. Functionally, we found that METTL3 could promote cell proliferation, invasion, and migration of GBC-SD and NOZ cells. Mechanisticall...
#1Erica Gentilin (UNIPD: University of Padua)H-Index: 3
#2E. D’Angelo (UNIPD: University of Padua)
Last. L. Astolfi (UNIPD: University of Padua)
view all 4 authors...
Today it is widely accepted that molecular mechanisms triggering cancer initiate with a genetic modification. However, a genetic alteration providing the aberrant clone with a growing advantage over neighboring cells is not sufficient to develop cancer. Currently, tumors are considered a heterogeneous population of cells and an extracellular matrix (ECM) that make up a characteristic microenvironment. Interactions between tumor cells and cancer microenvironment define cancer progression and ther...
#1Elyssa Sliheet (SMU: Southern Methodist University)
#2Molly Robinson (SMU: Southern Methodist University)
Last. John NemunaitisH-Index: 55
view all 9 authors...
Thus far immunotherapy has had limited impact on ovarian cancer. Vigil (a novel DNA-based multifunctional immune-therapeutic) has shown clinical benefit to prolong relapse-free survival (RFS) and overall survival (OS) in the BRCA wild type and HRP populations. We further analyzed molecular signals related to sensitivity of Vigil treatment. Tissue from patients enrolled in the randomized double-blind trial of Vigil vs. placebo as maintenance in frontline management of advanced resectable ovarian ...
#1Zhiqing Liu (CDUTCM: Chengdu University of Traditional Chinese Medicine)H-Index: 2
#2Shan Mu (CDUTCM: Chengdu University of Traditional Chinese Medicine)
Last. Hui Xie (CDUTCM: Chengdu University of Traditional Chinese Medicine)H-Index: 2
view all 14 authors...
Dysregulation of the cell cycle and the resulting aberrant cellular proliferation has been highlighted as a hallmark of cancer. Certain traditional Chinese medicines can inhibit cancer growth by inducing cell cycle arrest. In this study we explore the effect of Hedyotis diffusae Herba-Andrographis Herba on the cell cycle of nasopharyngeal carcinoma (NPC). Hedyotis diffusae Herba-Andrographis Herba-containing serum was prepared and then added to the cell culture medium. BrdU, comet, and FUCCI ass...
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