Cancer Gene Therapy
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#1Junqi Liu (Zhengzhou University)H-Index: 5
#2Runze Zhou (Zhengzhou University)H-Index: 1
Last. Di Zhao (Zhengzhou University)H-Index: 3
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Esophageal squamous cell carcinoma (ESCC) ranks as one of the most deadly cancers worldwide due to its aggressive progression and poor treatment response. The long non-coding RNA (lncRNA)-microRNA (miRNA)-messenger RNA (mRNA) axis has been highlighted as a potency biomarker for enhancing the radiosensitivity of ESCC. Hence, we investigated the functional mechanism of the lncRNA DIO3OS/miR-130b/PAX9 axis in the radioresistance of ESCC cells. In cell experiments, we altered the miR-130b expression...
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#1Ping Qinrong (Kunming Medical University)H-Index: 1
#2Ruping Yan (Kunming Medical University)H-Index: 7
Last. Ruhong Li (Kunming Medical University)H-Index: 7
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#1Lin Cao (Capital Medical University)H-Index: 1
#2Weisha Li (Peking Union Medical College)H-Index: 1
Last. Ran Gao (Peking Union Medical College)H-Index: 4
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Immunotherapies for cancer, such as immune checkpoint blockade or adoptive T-cell transfer, can lead to a long-lasting clinical response. But the therapeutic response rate remains low on account of many tumors that have evolved sophisticated strategies to evade immune surveillance. Solid tumors are characterized by the highly acidic microenvironment, which may weaken the effectiveness of antitumor immunity. Here, we explored a promising therapeutic development deployed by pH manipulation for avo...
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#1Xin-Xin He (Guangxi Medical University)
#2Shan-Shan Luo (Guangxi Medical University)
Last. Xianwei Mo (Guangxi Medical University)H-Index: 10
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Nuclear receptors (NRs) are a class of transcription factors that play a pivotal role in carcinogenesis, but their function in colorectal cancer (CRC) remains unclear. Here, we investigate the role NRs play in CRC pathogenesis. We found that hepatocyte nuclear factor 4 gamma (HNF4G; NR2A2), hepatocyte nuclear factor 4α (HNF4A; NR2A1), and retinoid-related orphan receptor γ (RORC; NR1F3) were significantly upregulated in CRC tissues analyzed by GEPIA bioinformatics tool. The expression of HNF4G w...
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#1Ramazan Rezaei (BMSU: Baqiyatallah University of Medical Sciences)
#2Hadi Esmaeili Gouvarchin Ghaleh (BMSU: Baqiyatallah University of Medical Sciences)H-Index: 3
Last. Akbar Ghorbani Alvanegh (BMSU: Baqiyatallah University of Medical Sciences)H-Index: 4
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Chimeric antigen receptor (CAR) T-cell therapy is an encouraging and fast-growing platform used for the treatment of various types of tumors in human body. Despite the recent success of CAR T-cell therapy in hematologic malignancies, especially in B-cell lymphoma and acute lymphoblastic leukemia, the application of this treatment approach in solid tumors faced several obstacles resulted from the heterogeneous expression of antigens as well as the induction of immunosuppressive tumor microenviron...
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#1Li-Ying Zhang (HMU: Harbin Medical University)
#2Jia-Ying Yu (HMU: Harbin Medical University)
Last. Xin-Chen Zhang (HMU: Harbin Medical University)
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Primary cytoreductive surgery with platinum-taxane-based chemotherapy is the standard treatment for ovarian cancer (OC) patients; however, resistance to chemotherapy is a contributing factor to OC mortality. Paclitaxel (PTX), the most widely used taxane, has become the first-line drug against OC. The molecular mechanism of PTX resistance is different from that of platinum-based agents and is still not completely elucidated. Our previous study showed that glucose-regulated protein 78 (GRP78) is i...
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#1Arjanneke F. van de Merbel (LUMC: Leiden University Medical Center)H-Index: 3
#2Geertje van der Horst (LUMC: Leiden University Medical Center)H-Index: 24
Last. Nadine van Montfoort (LUMC: Leiden University Medical Center)H-Index: 17
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Treatment of castration-resistant prostate cancer remains a challenging clinical problem. Despite the promising effects of immunotherapy in other solid cancers, prostate cancer has remained largely unresponsive. Oncolytic viruses represent a promising therapeutic avenue, as oncolytic virus treatment combines tumour cell lysis with activation of the immune system and mounting of effective anti-tumour responses. Mammalian Orthoreoviruses are non-pathogenic human viruses with a preference of lytic ...
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#1Yu-Hsuan Fu (NTU: National Taiwan University)H-Index: 2
#2Da-Liang Ou (NTU: National Taiwan University)H-Index: 11
Last. Liang-In Lin (NTU: National Taiwan University)H-Index: 32
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Cabozantinib is a potent tyrosine kinase inhibitor with multiple targets including MET, VEGFR2, RET, KIT, and FLT3. Cabozantinib is widely used for the treatment of medullary thyroid cancer and renal cell carcinoma. We recently suggested cabozantinib as a potential therapeutic alternative for acute myeloid leukemia (AML) patients with FLT3-internal tandem duplication (FLT3-ITD). Here, we report that cabozantinib can promote differentiation in erythroid leukemia cells. We found that K562 erythroi...
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#1Weiwen Fan (SYSU: Sun Yat-sen University)H-Index: 3
#2Miao Yu (SYSU: Sun Yat-sen University)H-Index: 2
Last. Konstantin Severinov (Skolkovo Institute of Science and Technology)H-Index: 73
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Genome editing tools targeting high-risk human papillomavirus (HPV) oncogene could be a promising therapeutic strategy for the treatment of HPV-related cervical cancer. We aimed to improve the editing efficiency and detect off-target effects concurrently for the clinical translation strategy by using CRISPR-Cas9 system co-transfected with 34nt non-homologous double-stranded oligodeoxynucleotide (dsODN). We firstly tested this strategy on targeting the Green Fluorescent Protein (GFP) gene, of whi...
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#1Qing Liu (Guangdong Pharmaceutical University)H-Index: 2
#2Haobin Li (Guangdong Pharmaceutical University)H-Index: 1
Last. Jiangchao Li (Guangdong Pharmaceutical University)H-Index: 14
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Epidermal growth factor receptor (EGFR) is widely accepted in cancer diagnosis and targeted therapy. Shkbp1 is an upstream molecule of EGFR, which prevents EGFR degradation. However, the role of Shkbp1 in tumor remains to be clarified. Herein we induced tumor in the lungs of Shkbp1 knockout mice with chemical drugs to investigate the function of Shkbp1. Compared with wild-type mice, tumors in the lungs were significantly fewer in Shkbp1 knockout mice. To further explore the biological characteri...
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Genetic enhancement
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