Distinct mTORC1 pathways for transcription and cleavage of SREBP-1c

In recent years, it has become increasingly apparent that common polygenic diseases generally do not result from accumulated defects in a single pathway but, rather, present as complex interactions among multiple environmental and inherited factors. Nowhere is this more obvious than in diabetes mellitus, which is classified into at least two groups, type 1 and type 2 (T2DM), that share hyperglycemia but differ in the initiating primary immune...