Neutropenia

Gene

Genetic enhancement

Intensive care medicine

Biology

Phagocyte

Surgery

Biochemistry

Primary immunodeficiency

Bone marrow

Immunology

Granulomatous disease

Immune system

Chronic granulomatous disease

Bone marrow transplantation

Chemotherapy

Medicine

Disease

Pathology

Hematology/Oncology Clinics of North America

Chronic granulomatous disease (CGD) is a paradigm for nonlymphoid primary immune defects, and has guided elucidation of oxygen metabolism in the phagocyte, vasculature, and brain. It has been in the forefront of the development of antimicrobial prophylaxis before the advent of advanced HIV and before its routine use in neutropenia. It has been an attractive target for gene therapy and bone marrow transplantation for nonmalignant diseases. Therefore, CGD is worthy of attention for its historical interest and because it is a disease for which expert management is imperative.

Chronic Granulomatous Disease