Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis
Abstract
Human osteoarthritis is a progressive disease of the joints characterized by degradation of articular cartilage. Although disease initiation may be multifactorial, the cartilage destruction appears to be a result of uncontrolled proteolytic extracellular matrix destruction. A major component of the cartilage extracellular matrix is aggrecan, a proteoglycan that imparts compressive resistance to the tissue. Aggrecan is cleaved at a specific...
Paper Details
Title
Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis
Published Date
Mar 31, 2005
Journal
Volume
434
Issue
7033
Pages
644 - 648
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Notes
History